Editorial
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Feb 26, 2017; 8(1): 21-31
Published online Feb 26, 2017. doi: 10.4331/wjbc.v8.i1.21
Biochemical changes in the injured brain
Seelora Sahu, Deb Sanjay Nag, Amlan Swain, Devi Prasad Samaddar
Seelora Sahu, Deb Sanjay Nag, Amlan Swain, Devi Prasad Samaddar, Department of Anaesthesia and Critical Care, Tata Main Hospital, Jamshedpur 831001, India
Author contributions: All the authors contributed to the manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Deb Sanjay Nag, Department of Anaesthesia and Critical Care, Tata Main Hospital, C Road West, Northern Town, Bistupur, Jamshedpur 831011, India. debsanjay@gmail.com
Telephone: +91-943-1166582 Fax: +91-657-2224559
Received: August 30, 2016
Peer-review started: September 1, 2016
First decision: September 29, 2016
Revised: October 23, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: February 26, 2017
Processing time: 180 Days and 14.5 Hours
Core Tip

Core tip: The biochemical markers of brain injury are being increasingly used to assess the severity and prognosis in the injured brain. While S-100, glial fibrillary acidic protein and ubiquitin C terminal hydrolase have been used as early biomarkers to aid in clinical decision-making and initial management, other biomarkers help in long-term prognosis. Cerebral microdialysis is a novel way of monitoring brain tissue biochemical metabolites and each component gives an idea about the severity and type of pathologic process in the brain. In addition, small non-coding RNAs have presented themselves as potential markers of brain injury for future research.