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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Nov 26, 2016; 7(4): 231-239
Published online Nov 26, 2016. doi: 10.4331/wjbc.v7.i4.231
Published online Nov 26, 2016. doi: 10.4331/wjbc.v7.i4.231
Mechanisms of the alternative activation of macrophages and non-coding RNAs in the development of radiation-induced lung fibrosis
Nadire Duru, Benjamin Wolfson, Qun Zhou, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
Author contributions: Duru N and Wolfson B contributed equally to this manuscript; Duru N wrote the manuscript; Wolfson B wrote and reviewed the manuscript; Zhou Q designed the aim of the review and reviewed the manuscript.
Conflict-of-interest statement: There are no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Qun Zhou, MD, PhD, Associate Professor, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, United States. qzhou@som.umaryland.edu
Telephone: +1-410-7061615 Fax: +1-410-7068297
Received: July 28, 2016
Peer-review started: July 31, 2016
First decision: September 2, 2016
Revised: September 17, 2016
Accepted: October 25, 2016
Article in press: October 27, 2016
Published online: November 26, 2016
Processing time: 112 Days and 20 Hours
Peer-review started: July 31, 2016
First decision: September 2, 2016
Revised: September 17, 2016
Accepted: October 25, 2016
Article in press: October 27, 2016
Published online: November 26, 2016
Processing time: 112 Days and 20 Hours
Core Tip
Core tip: We discuss the mechanisms of initiation and progression of radiation-induced lung fibrosis. First we summarize the role of M2 macrophages in the initiation and development of pulmonary fibrosis with an emphasis on their function in radiation-induced lung fibrosis. We then examine the growing evidence describing non-coding RNAs in the development and progression of radiation-induced lung fibrosis.