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World J Biol Chem. Feb 26, 2016; 7(1): 146-157
Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.146
Regulation of RNA binding proteins in trypanosomatid protozoan parasites
María Albertina Romaniuk, Gabriela Cervini, Alejandro Cassola
María Albertina Romaniuk, Gabriela Cervini, Alejandro Cassola, Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús, UNSAM-CONICET, 1650 San Martín, Provincia de Buenos Aires, Argentina
Author contributions: Romaniuk MA generated the tables and reviewed the manuscript; Cervini G reviewed the manuscript; Cassola A designed the aim of the review, wrote the manuscript and generated the tables.
Supported by The Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) to Alejandro Cassola.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alejandro Cassola, PhD, Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús, UNSAM-CONICET, 1650 San Martín, Provincia de Buenos Aires, Argentina. acassola@iibintech.com.ar
Telephone: +54-11-40061500 Fax: +54-11-40061559
Received: May 28, 2015
Peer-review started: June 1, 2015
First decision: August 8, 2015
Revised: October 1, 2015
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: February 26, 2016
Processing time: 273 Days and 16.8 Hours
Core Tip

Core tip: We discuss several ways to regulate the function of RNA-binding proteins in trypanosomes. We highlight the propensity of these proteins to engage in interactions with other proteins and RNA, resulting in the formation of large reversible aggregates induced by environmental stress. Finally, the possible role of posttranslational modifications on the function of these proteins is discussed in the context of recent high-throughput proteomic evidences.