Review
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Feb 26, 2016; 7(1): 1-13
Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.1
Yersinia type III effectors perturb host innate immune responses
Khavong Pha, Lorena Navarro
Khavong Pha, Lorena Navarro, Department of Microbiology and Molecular Genetics, University of California, Davis, CA 95616, United States
Author contributions: Pha K and Navarro L solely contributed to this paper.
Supported by The ASM Robert D Watkins Graduate Fellowship and UC Davis Hellman Fellowship.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lorena Navarro, PhD, Department of Microbiology and Molecular Genetics, University of California, One Shields Avenue, 255 Briggs Hall, Davis, CA 95616, United States. lonavarro@ucdavis.edu
Telephone: +1-530-7520260 Fax: +1-530-7529014
Received: June 25, 2015
Peer-review started: June 25, 2015
First decision: August 16, 2015
Revised: September 2, 2015
Accepted: November 3, 2015
Article in press: November 4, 2015
Published online: February 26, 2016
Processing time: 245 Days and 16.7 Hours
Core Tip

Core tip: The study of Yersinia type III secretion system effector proteins has provided critical insights into bacterial pathogenic strategies and host innate immune responses. Identification of the crystal structure of YpkA revealed how a bacterial effector can counteract phagocytosis at multiple levels including inhibition of actin polymerization by sequestering actin, inhibition of actin signaling molecules via both its kinase and dissociation-like inhibitor domains, and inhibition of actin-cytoskeletal components via phosphorylation. YpkA/YopO multisite autophosphorylation may allow YpkA/YopO to bypass regulation by host phosphatases and thus prolong its ability to interfere with phagocytosis. Additionally, an emerging theme is the role of caspases in anti-Yersinia host defenses.