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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Nov 26, 2015; 6(4): 351-357
Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.351
Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.351
Klotho in cardiovascular disease: Current and future perspectives
Javier Donate-Correa, Ernesto Martín-Núñez, Carmen Mora-Fernández, Juan F Navarro-González, Research Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Mercedes Muros-de-Fuentes, Nayra Pérez-Delgado, Clinical Biochemistry Service, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Juan F Navarro-González, Nephrology Service, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Author contributions: Donate-Correa J, Martín-Núñez E, Mora-Fernández C, Muros-de-Fuentes M and Pérez-Delgado N cooperated in the design and the writing; Navarro-González JF revised and polished the text.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Javier Donate-Correa, PhD, Research Unit, University Hospital Nuestra Señora de Candelaria, Ctra. Gral. del Rosario, 145, 38010 Santa Cruz de Tenerife, Spain. jdonate@ull.es
Telephone: +34-922-602061 Fax: +34-922-600562
Received: May 28, 2015
Peer-review started: May 28, 2015
First decision: July 20, 2015
Revised: July 31, 2015
Accepted: September 7, 2015
Article in press: September 8, 2015
Published online: November 26, 2015
Processing time: 178 Days and 17.1 Hours
Peer-review started: May 28, 2015
First decision: July 20, 2015
Revised: July 31, 2015
Accepted: September 7, 2015
Article in press: September 8, 2015
Published online: November 26, 2015
Processing time: 178 Days and 17.1 Hours
Core Tip
Core tip: Protein Klotho, beyond its role as a regulator of the phosphatemia, has also been involved in the maintaining of the cardiovascular health. For all this, is the subject of a thorough research which focused on uncover its intimate mechanisms of action, and in analyzing the utility of its modulation as a potential strategy for clinical applicability. Emerging research links Klotho deficiency with vascular pathology. Changes in this protein have been associated, among others cardiovascular-related complications, with inflammation, vascular calcification, and endothelial dysfunction.