Rennoll S, Yochum G. Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer. World J Biol Chem 2015; 6(4): 290-300 [PMID: 26629312 DOI: 10.4331/wjbc.v6.i4.290]
Corresponding Author of This Article
Gregory Yochum, PhD, Department of Biochemistry and Molecular Biology, the Pennsylvania State University College of Medicine, Mail code H171, PO Box 850, Hershey, PA 17033-0850, United States. gsy3@psu.edu
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Biol Chem. Nov 26, 2015; 6(4): 290-300 Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.290
Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer
Sherri Rennoll, Gregory Yochum
Sherri Rennoll, Gregory Yochum, Department of Biochemistry and Molecular Biology, the Pennsylvania State University College of Medicine, Hershey, PA 17033-0850, United States
Author contributions: Rennoll S and Yochum G wrote the paper.
Supported by Institutional funds provided by the Pennsylvania State University College of Medicine.
Conflict-of-interest statement: Authors declare no conflicts of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Gregory Yochum, PhD, Department of Biochemistry and Molecular Biology, the Pennsylvania State University College of Medicine, Mail code H171, PO Box 850, Hershey, PA 17033-0850, United States. gsy3@psu.edu
Telephone: +1-717-5312091 Fax: +1-717-5317072
Received: June 10, 2015 Peer-review started: June 14, 2015 First decision: August 25, 2015 Revised: August 26, 2015 Accepted: October 12, 2015 Article in press: October 13, 2015 Published online: November 26, 2015 Processing time: 166 Days and 7.1 Hours
Core Tip
Core tip: In colon cancer, mutations in components of the Wnt/β-catenin signaling pathway result in inappropriate c-MYC proto-oncogene (MYC) expression. To understand colorectal carcinogenesis requires the identification of Wnt responsive DNA elements (WREs) that control MYC expression in colorectal cancer (CRC). Through efforts to characterize MYC WREs, a model has emerged where several of these WREs appear largely dispensable for intestinal homeostasis, but are instead “hijacked” by oncogenic Wnt/β-catenin signaling to drive CRC. These findings raise the intriguing possibility that these WREs may be targeted therapeutically as an alternative approach to treat individuals afflicted by CRC. In this review, we summarize the literature describing the identification of MYC WREs and discuss how those involved in colorectal carcinogenesis may be targeted to limit progression of CRC.
