Lee S, Choi E, Kim SM, Hwang KC. MicroRNAs as mediators of cardiovascular disease: Targets to be manipulated. World J Biol Chem 2015; 6(2): 34-38 [PMID: 26009702 DOI: 10.4331/wjbc.v6.i2.34]
Corresponding Author of This Article
Ki-Chul Hwang, PhD, Distinguished Professor, Director of the Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, 24 Beomil-ro 579beon-gil, Gangneung, Gangwon-do 210-701, South Korea. kchwang@cku.ac.kr
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Biol Chem. May 26, 2015; 6(2): 34-38 Published online May 26, 2015. doi: 10.4331/wjbc.v6.i2.34
MicroRNAs as mediators of cardiovascular disease: Targets to be manipulated
Seahyoung Lee, Eunhyun Choi, Sung-Man Kim, Ki-Chul Hwang
Seahyoung Lee, Eunhyun Choi, Sung-Man Kim, Ki-Chul Hwang, Catholic Kwandong University International St. Mary’s Hospital, Incheon Metropolitan City 404-834, South Korea
Seahyoung Lee, Eunhyun Choi, Ki-Chul Hwang, Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung, Gangwon-do 210-701, South Korea
Author contributions: Lee S and Choi E wrote the manuscript; Kim SM and Hwang KC edited the manuscript.
Supported by A Korea Science and Engineering Foundation grant funded by the Korean government (MEST), NRF-2011-0019243 and NRF-2011-0019254; and a grant from the Korea Health 21 RD Project, Ministry of Health and Welfare, Republic of Korea, No. A120478.
Conflict-of-interest: All authors declare no conflict-of-interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ki-Chul Hwang, PhD, Distinguished Professor, Director of the Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, 24 Beomil-ro 579beon-gil, Gangneung, Gangwon-do 210-701, South Korea. kchwang@cku.ac.kr
Telephone: +82-32-2903883 Fax: +82-32-2902774
Received: January 28, 2015 Peer-review started: January 29, 2015 First decision: March 6, 2015 Revised: March 17, 2015 Accepted: April 16, 2015 Article in press: April 20, 2015 Published online: May 26, 2015 Processing time: 112 Days and 21.9 Hours
Core Tip
Core tip: Accumulating evidence indicates that microRNAs (miRNAs) play important roles in the development and progression of cardiovascular diseases. To date, observational studies such as miRNA-profiling in diseased animals and/or patients have provided valuable information regarding their roles in cardiovascular diseases. For example, dysregulated miRNAs under pathologic conditions have been identified, and their possible targets, whose down-regulation may have contributed to the development of corresponding disease, have been examined. Nevertheless, future studies should be more focused on identifying key mechanisms of miRNA dysregulation during pathogenesis of the cardiovascular system so that optimized counter-measures to prevent/manage cardiovascular disease can be designed and developed.
