Editorial
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Aug 26, 2014; 5(3): 269-274
Published online Aug 26, 2014. doi: 10.4331/wjbc.v5.i3.269
Can short-term fasting protect against doxorubicin-induced cardiotoxicity?
Amie J Dirks-Naylor, Samir A Kouzi, Sendra Yang, Ngan TK Tran, Joseph D Bero, Raean Mabolo, Diep T Phan, Stephanie D Whitt, Heather N Taylor
Amie J Dirks-Naylor, Samir A Kouzi, Sendra Yang, Ngan TK Tran, Joseph D Bero, Raean Mabolo, Diep T Phan, Stephanie D Whitt, Heather N Taylor, School of Pharmacy, Wingate University, Wingate, NC 28174, United States
Author contributions: Dirks-Naylor AJ and Kouzi SA wrote the mansucript and involved in data collection; Yang S, Tran NTK, Bero JD, Mabolo R, Phan DT, Whitt SD and Taylor HN involved in data collection and editing the manuscript.
Correspondence to: Amie J Dirks-Naylor, PhD, Associate Professor, School of Pharmacy, Wingate University, 515 N. Main Street, Wingate, NC 28174, United States. anaylor@wingate.edu
Telephone: +1-704-2338341 Fax: +1-704-2338332
Received: February 19, 2014
Revised: May 6, 2014
Accepted: June 10, 2014
Published online: August 26, 2014
Processing time: 203 Days and 11.4 Hours
Core Tip

Core tip: Doxorubicin (Dox)-induced cardiotoxicity remains a significant cause of morbidity and mortality in cancer survivors, despite the intensive investigation of potential protective strategies. Studies have shown that short-term fasting induces cardioprotective effects against Dox-induced injury. Importantly, evidence suggests that fasting may enhance the antitumor effects of Dox. Thus, short-term fasting may be a feasible practice that can easily be incorporated into the treatment plans of cancer patients.