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World J Biol Chem. May 26, 2014; 5(2): 216-223
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.216
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.216
FBW7-mediated ubiquitination and degradation of KLF5
Yi Luan, Ping Wang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
Author contributions: Luan Y and Wang P contributed equally to this paper.
Supported by Grants from National Basic Research Program of China, 973 program, No. 2010CB529704 and No. 2012CB910404; National Natural Science Foundation of China, No. 30800587, No. 30971521, and No. 31171338; and the Science and Technology Commission of Shanghai Municipality, No. 11DZ2260300; a scholar of the Shanghai Rising-Star Program from Science and Technology Commission of Shanghai Municipality, No. 09QA1401900 to Wang P
Correspondence to: Ping Wang, PhD, Professor, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. pwang@bio.ecnu.edu.c
Telephone: +86-21-54345021 Fax: +86-21-54344922
Received: November 14, 2013
Revised: January 15, 2014
Accepted: March 17, 2014
Published online: May 26, 2014
Processing time: 208 Days and 17.4 Hours
Revised: January 15, 2014
Accepted: March 17, 2014
Published online: May 26, 2014
Processing time: 208 Days and 17.4 Hours
Core Tip
Core tip: The protein levels of Krüppel-like factor (KLF)5 are tightly controlled in cell. Ubiquitination and destruction of KLF5 via FBW7, a famous tumor suppressor, has proved to have important roles in multiple cellular progresses by different studies. Here, we summarize these studies and show the physiological and pathological significance of FBW7-mediated degradation of KLF5.