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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. May 26, 2014; 5(2): 169-179
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.169
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.169
Activated protein C: A regulator of human skin epidermal keratinocyte function
Kelly McKelvey, Christopher John Jackson, Meilang Xue, Sutton Arthritis Research Laboratory, Level 10, Kolling Institute, University of Sydney at Royal North Shore Hospital, NSW 2065, Australia
Author contributions: McKelvey K and Xue M contributed equally in writing the manuscript; Jackson CJ provided critique and comment on the manuscript.
Supported by Ulysses Club Arthritis Research Fellowship; and Henry Langley Arthritis Research Fellowship respectively, to McKelvey K and Xue M
Correspondence to: Dr. Meilang Xue, Sutton Arthritis Research Laboratory, Level 10, Kolling Institute, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. meilang.xue@sydney.edu.au
Telephone: +61-2-99264816 Fax: +61-2-99266269
Received: October 23, 2013
Revised: January 20, 2014
Accepted: April 3, 2014
Published online: May 26, 2014
Processing time: 231 Days and 1.9 Hours
Revised: January 20, 2014
Accepted: April 3, 2014
Published online: May 26, 2014
Processing time: 231 Days and 1.9 Hours
Core Tip
Core tip: The anti-inflammatory, barrier stabilisation and anti-apoptotic properties of APC make it an appealing treatment for skin conditions associated with inflammation, barrier disruption and keratinocyte dysfunction.