Barbosa EG, Aburjaile FF, Ramos RT, Carneiro AR, Le Loir Y, Baumbach J, Miyoshi A, Silva A, Azevedo V. Value of a newly sequenced bacterial genome. World J Biol Chem 2014; 5(2): 161-168 [PMID: 24921006 DOI: 10.4331/wjbc.v5.i2.161]
Corresponding Author of This Article
Vasco Azevedo, MD, PhD, Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Univeridade Federal de Minas Gerais, Av. Antônio Carlos 6627 Pampulha, Belo Horizonte 31270-901, Brazil. vasco@icb.ufmg.br
Research Domain of This Article
Biotechnology & Applied Microbiology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Biol Chem. May 26, 2014; 5(2): 161-168 Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.161
Value of a newly sequenced bacterial genome
Eudes GV Barbosa, Flavia F Aburjaile, Rommel TJ Ramos, Adriana R Carneiro, Yves Le Loir, Jan Baumbach, Anderson Miyoshi, Artur Silva, Vasco Azevedo
Eudes GV Barbosa, Flavia F Aburjaile, Anderson Miyoshi, Vasco Azevedo, Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901 MG, Brazil
Eudes GV Barbosa, Jan Baumbach, Department of Mathematics and Computer Science, University of Southern Denmark, 5230 Odense, Denmark
Flavia F Aburjaile, Yves Le Loir, INRA, UMR1253, Science et Technologie du Lait et de l’Œuf, F-35042 Rennes, France
Rommel TJ Ramos, Adriana R Carneiro, Artur Silva, Laboratório de Polimorfismo de DNA, Instituto de Ciências Biológicas, Univeridade Federal do Pará, Belém 66075-110, Brazil
Author contributions: All authors contributed extensively to the work presented in this review.
Supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) in Brazil, processes BEX 12954-12-8 and 11517-12-3, to Barbosa EGV and Aburjaile FF
Correspondence to: Vasco Azevedo, MD, PhD, Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Univeridade Federal de Minas Gerais, Av. Antônio Carlos 6627 Pampulha, Belo Horizonte 31270-901, Brazil. vasco@icb.ufmg.br
Telephone: +55-31-34092873 Fax: +55-31-34092610
Received: December 11, 2013 Revised: January 14, 2014 Accepted: April 3, 2014 Published online: May 26, 2014 Processing time: 181 Days and 10.5 Hours
Core Tip
Core tip: Next-generation sequencing (NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of bacterial genomes has not only brought excitement to the field of genomics, it has also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has consequences for genome quality, resulting in an exponential increase in draft genome deposits in public databases. This review will address the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology, as well as the impact of NGS on draft bacterial genomes.
