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World J Biol Chem. May 26, 2014; 5(2): 130-140
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.130
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.130
What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders?
Maria da Graça Naffah-Mazzacoratti, Telma Luciana Furtado Gouveia, Priscila Santos Rodrigues Simões, Sandra Regina Perosa, Department de Bioquímica and Departamento de Neurologia/Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 4039032, Brazil
Author contributions: Gouveia TLF worked on renin-angiotensin systems in epilepsy; Simões PSR worked on kallikrein and other enzymes related to this system; and Perosa SR worked with kinins and their receptors in the CNS; Naffah-Mazzacoratti MG guided all the work, wrote and organized the manuscript.
Supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); and Instituto Nacional de Neurociência Translacional (INNT), Programa de Núcleos de Excelência (PRONEX) (Brazil)
Correspondence to: Maria da Graça Naffah-Mazzacoratti, PhD, Departamento de Bioquímica, Universidade Federal de São Paulo, Rua Pedro de Toledo 669, segundo andar, São Paulo, SP 4039032, Brasil. naffahmazzacoratti@gmail.com
Telephone: +55-11-55764848-1356 Fax: +55-11-55764848-2838
Received: November 15, 2013
Revised: February 10, 2014
Accepted: March 17, 2014
Published online: May 26, 2014
Processing time: 209 Days and 9.7 Hours
Revised: February 10, 2014
Accepted: March 17, 2014
Published online: May 26, 2014
Processing time: 209 Days and 9.7 Hours
Core Tip
Core tip: This review is a description of the involvement of the kallikrein-kinin and renin-angiotensin systems in neurological disorders. We describe all components of both systems, relating them to several brain diseases such as Alzheimer’s disease, Parkinson’s disease, epilepsy, multiple sclerosis, blood brain barrier disruption, stroke and inflammation, including the involvement of each molecule, their receptor and specific enzymes in individual pathologies. We also show that brain homeostasis depends on a dynamic balance between the kallikrein-kinin and renin-angiotensin systems.