Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.106
Revised: January 16, 2014
Accepted: March 3, 2014
Published online: May 26, 2014
Processing time: 204 Days and 9.4 Hours
Core tip: Mass spectrometric based proteomics has been an indispensable tool for molecular and cellular biology. The ability of mass spectrometry to identify and precisely quantify thousands of proteins from complex samples has contributed greatly to biology and medicine. Through this we have studied protein-protein interactions via affinity-based isolations on a small and proteome-wide scale, the mapping of numerous organelles, and the generation of quantitative protein profiles from diverse species. The anterior segment of the eye is one of the most complicated parts of the human body with over 5000 proteins identified. Proteomic analyses of different parts of the eye, in particular the anterior eye structures, involve high throughput methods that help identify proteins and their posttranslational modifications. In this article we review the current state of advancement in the identification of anterior chamber proteins. We will present our findings in the following order: cornea, aqueous humor, trabecular meshwork, ciliary body, iris and lens.