Vislovukh A, Vargas TR, Polesskaya A, Groisman I. Role of 3’-untranslated region translational control in cancer development, diagnostics and treatment. World J Biol Chem 2014; 5(1): 40-57 [PMID: 24600513 DOI: 10.4331/wjbc.v5.i1.40]
Corresponding Author of This Article
Irina Groisman, PhD, Commissariat à l’Energie Atomique (CEA), Saclay, Bat. 144-Point courrier n 22, F-91191 Gif-sur-Yvette, France. irina.groisman@cea.fr
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
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World J Biol Chem. Feb 26, 2014; 5(1): 40-57 Published online Feb 26, 2014. doi: 10.4331/wjbc.v5.i1.40
Role of 3’-untranslated region translational control in cancer development, diagnostics and treatment
Andrii Vislovukh, Thaiz Rivera Vargas, Anna Polesskaya, Irina Groisman
Andrii Vislovukh, State Key Laboratory of Molecular and Cellular Biology, Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Kyiv 03680, Ukraine
Thaiz Rivera Vargas, Anna Polesskaya, Irina Groisman, Université Paris Sud, Laboratoire Epigénétique et Cancer, Formation de Recherche Evolution 3377, F-91191 Gif-Sur-Yvette, France
Thaiz Rivera Vargas, Anna Polesskaya, Irina Groisman, Centre National de la Recherche Scientifique (CNRS), F-91191 Gif-Sur-Yvette, France
Thaiz Rivera Vargas, Anna Polesskaya, Irina Groisman, Commissariat à l’Energie Atomique (CEA), Saclay, F-91191 Gif-sur-Yvette, France
Author contributions: Vislovukh A, Vargas TR, Polesskaya A and Groisman I contributed to this paper.
Correspondence to: Irina Groisman, PhD, Commissariat à l’Energie Atomique (CEA), Saclay, Bat. 144-Point courrier n 22, F-91191 Gif-sur-Yvette, France. irina.groisman@cea.fr
Telephone: +33-1-69085376 Fax: +33-1-69084712
Received: October 28, 2013 Revised: November 27, 2013 Accepted: December 17, 2013 Published online: February 26, 2014 Processing time: 142 Days and 1 Hours
Core Tip
Core tip: The messenger RNA 3’-untranslated region (3’UTR) plays an important role in regulation of gene expression on the posttranscriptional level. 3’UTR controls gene expression via orchestrated interaction between structural components mRNAs (cis-element) and specific trans-acting factors (RNA binding proteins and non-coding RNAs). Alteration of any of these components can lead to various pathologies. In this review we will discuss how alteration of these factors or a change in the crosstalk between them can affect cancer development and promote or enhance the malignant phenotype of cancer cells. Understanding these regulatory mechanisms and their impact on 3’UTR-directed posttranscriptional gene regulation may uncover promising new targets for therapeutic intervention and diagnostics.
