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World J Biol Chem. Nov 26, 2013; 4(4): 91-101
Published online Nov 26, 2013. doi: 10.4331/wjbc.v4.i4.91
Cathepsins mediate tumor metastasis
Gong-Jun Tan, Zheng-Ke Peng, Jin-Ping Lu, Fa-Qing Tang
Gong-Jun Tan, Fa-Qing Tang, Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Gong-Jun Tan, Zheng-Ke Peng, Jin-Ping Lu, Fa-Qing Tang, Department of Clinical Laboratory, Zhuhai Hospital, Jinan of University, Zhuhai 519000, Guangdong Province, China
Author contributions: All authors contributed equally to this study.
Supported by National Natural Science Foundation of China, No. 81071718, No. 81000881, No. 81372282 and No. 30973400; Fundamental Research Funds for the Central Universities, No. 21611612; Guangdong Natural Science Foundation, No. S2013010013360 and the Foundation of State Key Laboratory of Oncology in South China, No. HN2011-04
Correspondence to: Fa-Qing Tang, Professor, Department of Clinical Laboratory, Zhuhai Hospital, Jinan of University, 79 Kangning Road, Xiangzhou District, Zhuhai 519000, Guangdong, China. tangfaqing33@hotmail.com
Telephone: +86-756-2157645 Fax: +86-756-2157634
Received: August 12, 2013
Revised: September 6, 2013
Accepted: September 14, 2013
Published online: November 26, 2013
Processing time: 116 Days and 0.7 Hours
Core Tip

Core tip: Cathepsins play an important role in tumor metastasis, as a superfamily, each member experts different function in tumor metastatic process. In the present, we summarized the roles of cathepsin family members and analyzed their mechanism in tumor metastasis. These provide a novel insight in tumor metastasis.