Original Article
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World J Biol Chem. Nov 26, 2013; 4(4): 119-130
Published online Nov 26, 2013. doi: 10.4331/wjbc.v4.i4.119
Effect of alcohol exposure on hepatic superoxide generation and hepcidin expression
Duygu Dee Harrison-Findik, Sizhao Lu, Emily M Zmijewski, Jocelyn Jones, Matthew C Zimmerman
Duygu Dee Harrison-Findik, Sizhao Lu, Emily M Zmijewski, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, United States
Jocelyn Jones, Matthew C Zimmerman, Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, United States
Author contributions: Lu S, Zmijewski EM and Jones J performed the experiments and helped with the manuscript; Harrison-Findik DD and Zimmerman MC designed the study, wrote and edited the manuscript.
Supported by Grant to Harrison-Findik DD, No. NIH R01AA017738; University of Nebraska Medical Center Undergraduate Scholarship to Lu S EPR spectroscopy studies were conducted in the EPR Core Facility, which is supported by the University of Nebraska-Lincoln Redox Biology Center, No. NIH 1 P30 GM103335
Correspondence to: Duygu Dee Harrison-Findik, PhD, Department of Internal Medicine, University of Nebraska Medical Center, 95820 UNMC, DRC I, Omaha, NE 68198-5820, United States. dharrisonfindik@unmc.edu
Telephone: +1-402-5596355 Fax: +1-402-5596494
Received: August 21, 2013
Revised: November 5, 2013
Accepted: November 15, 2013
Published online: November 26, 2013
Processing time: 107 Days and 11.3 Hours
Core Tip

Core tip: Patients with alcoholic liver disease frequently exhibit iron overload, which contributes to liver injury. Our previous research has shown that suppression of iron-regulatory hormone, hepcidin by alcohol-mediated oxidative stress in the liver is involved. This manuscript investigates the role of superoxide and mitochondria in this process by using MnSOD knockout mice.