Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Mar 5, 2025; 16(1): 98515
Published online Mar 5, 2025. doi: 10.4331/wjbc.v16.i1.98515
Bioactivity of dressings based on platelet-rich plasma and Platelet-rich fibrin for tissue regeneration in animal model
João Abel Sá-Oliveira, Monique Vieira Geraldo, Milena Marques, Rafael Messias Luiz, Filipe Krasinski Cestari, Ingrid Nascimento Lima, Thayná Cristine De Souza, Ana Carla Zarpelon-Schutz, Kádima Nayara Teixeira
João Abel Sá-Oliveira, Kádima Nayara Teixeira, Programa Multicêntrico de Pós-graduação em Bioquímica e Biologia Molecular - Setor Palotina, Universidade Federal do Paraná, Palotina 85950-000, Paraná, Brazil
Monique Vieira Geraldo, Milena Marques, Rafael Messias Luiz, Ingrid Nascimento Lima, Ana Carla Zarpelon-Schutz, Kádima Nayara Teixeira, Campus Toledo, Universidade Federal do Paraná, Toledo 85919-899, Paraná, Brazil
Filipe Krasinski Cestari, Patologia, Laboratório Prevenção Patologia, Cascavel 85810-040, Paraná, Brazil
Thayná Cristine De Souza, Medicina-Campus Toledo, UFPR - Universidade Federal do Paraná, Toledo 85919-899, Paraná, Brazil
Ana Carla Zarpelon-Schutz, Programa de Pós-graduação em Biotecnologia-Setor Palotina, Universidade Federal do Paraná, Palotina 85950-000, Paraná, Brazil
Author contributions: Sá-Oliveira JA, Geraldo MV, Marques M and Luiz RM performed the in vivo experiments; Lima IN and De Souza TC carried out the pilot tests; Sá-Oliveira JA performed histology; Sá-Oliveira JA and Cestari FK analyze histology; Sá-Oliveira JA, Zarpelon-Schutz AC and Teixeira KN wrote manuscript; Zarpelon-Schutz AC and Teixeira KN interpreted the data, performed the critical analysis of the results and coordinated the study. All authors approved the final version of the manuscript.
Institutional review board statement: The Institutional Review Board declares knowledge about the study.
Institutional animal care and use committee statement: The Institutional Animal Care and Use Committee declares knowledge and approval about the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The authors declare that all data are public and can be shared upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kádima Nayara Teixeira, PhD, Professor, Researcher, Campus Toledo, Universidade Federal do Paraná, Max Planck 3796, Toledo 85919-899, Paraná, Brazil. kadimateixeira@ufpr.br
Received: June 28, 2024
Revised: October 14, 2024
Accepted: December 5, 2024
Published online: March 5, 2025
Processing time: 249 Days and 19.4 Hours
Core Tip

Core Tip: This study compares the effects of dressings made from platelet concentrates platelet-rich fibrin (PRF), platelet-rich plasma, and PRF activated with CaCl2 - on accelerating the tissue repair process and closing cutaneous wounds in Wistar rats. The results indicated that the PRF dressing accelerated wound closure and tissue repair.