Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Mar 27, 2023; 14(2): 52-61
Published online Mar 27, 2023. doi: 10.4331/wjbc.v14.i2.52
Correlation of serum SARS-CoV-2 IgM and IgG serology and clinical outcomes in COVID-19 patients: Experience from a tertiary care centre
Mohan Suresh, Pratap Kumar, Prasan Kumar Panda, Vikram Jain, Rohit Raina, Sarama Saha, Subbiah Vivekanandhan, Balram Ji Omar
Mohan Suresh, Pratap Kumar, Prasan Kumar Panda, Vikram Jain, Rohit Raina, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh 249203, India
Sarama Saha, Subbiah Vivekanandhan, Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh 249203, India
Balram Ji Omar, Department of Microbiology, All India Institute of Medical Sciences, Rishikesh 249203, India
Author contributions: Panda PK, and Vivekanandhan V contributed to conceptualization; Panda PK contributed to methodology; Raina R contributed to software; Panda PK, Jain V, Suresh M, Omar BJ, and Kumar P contributed to validation; Raina R contributed to formal analysis; Saha S contributed to investigation; Panda PK contributed to resources; Suresh M contributed to data curation; Suresh M and Kumar P contributed to writing-original draft preparation; Panda PK and Omar BJ contributed to writing-review and editing; Panda PK contributed to visualization; Panda PK, Saha S, and Vivekanandhan V contributed to supervision; Panda PK, and Vivekanandhan V contributed to project administration; All authors have read and agreed to the published version of the manuscript.
Institutional review board statement: The Approval for this study was obtained from the institute ethics committee of All India Institute of Medical Sciences Rishikesh with approval no CTRI/2020/08/027169.
Informed consent statement: Consent is waived considering de-identification of the patient data.
Conflict-of-interest statement: We declare that we have no conflicts of interest and it’s not funded.
Data sharing statement: It will be made available to others as required upon requesting the corresponding author.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Prasan Kumar Panda, MBBS, MD, Associate Professor, Department of Internal Medicine, All India Institute of Medical Sciences, Rishikesh 249203, India. motherprasanna@rediffmail.com
Received: October 10, 2022
Peer-review started: October 10, 2022
First decision: January 3, 2023
Revised: January 12, 2023
Accepted: February 13, 2023
Article in press: February 13, 2023
Published online: March 27, 2023
Core Tip

Core Tip: Coronavirus disease 2019 (COVID-19) serology levels are high in reverse transcriptase polymerase chain reaction positive group compared to clinical COVID-19. However, serology cannot be useful for the prediction of disease outcomes. The study also highlights the importance of doing serology at a particular time as antibody titres vary with the duration of the disease. In week interval there were significant correlation with clinical outcomes and serology on week 3.