Meta-Analysis
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Nov 27, 2021; 12(6): 114-130
Published online Nov 27, 2021. doi: 10.4331/wjbc.v12.i6.114
Remission is not maintained over 2 years with hematopoietic stem cell transplantation for rheumatoid arthritis: A systematic review with meta-analysis
Sathish Muthu, Madhan Jeyaraman, Rajni Ranjan, Saurabh Kumar Jha
Sathish Muthu, Madhan Jeyaraman, Saurabh Kumar Jha, Department of Biotechnology, School of Engineering and Technology, Sharda University, Delhi 201306, Uttar Pradesh, India
Sathish Muthu, Department of Orthopaedics, Government Medical College and Hospital, Dindigul 624001, Tamil Nadu, India
Madhan Jeyaraman, Department of Orthopaedics, Faculty of Medicine, Sri Lalithambigai Medical College and Hospital, Chennai 600095, Tamil Nadu, India
Rajni Ranjan, Department of Orthopaedics, School of Medical Sciences and Research, Greater Noida 201306, Uttar Pradesh, India
Author contributions: Muthu S and Jeyaraman M provide the conceptualization; Muthu S, Jeyaraman M, and Ranjan R contributed to the data curation, formal analysis, investigations, methodology; Muthu S and Ranjan R contributed to the administration, resources, and supervision; Muthu S contributed to the validation and visualization; Muthu S and Jeyaraman M contributed to writing the original draft and reviewing the drafts.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sathish Muthu, MS, Research Scholar, School of Engineering and Technology, Sharda University, Greater Noida, Delhi 201306, Uttar Pradesh, India. drsathishmuthu@gmail.com
Received: March 30, 2021
Peer-review started: March 30, 2021
First decision: May 12, 2021
Revised: May 21, 2021
Accepted: November 26, 2021
Article in press: November 26, 2021
Published online: November 27, 2021
Processing time: 258 Days and 17.8 Hours
Core Tip

Core Tip: With the rising resistance to the traditional disease-modifying anti-rheumatic drugs and targeted biological therapy, we performed this systematic review and meta-analysis to evaluate the role of hematopoietic stem cell therapy in the management of rheumatoid arthritis. Literature on the effectiveness of the intervention is encouraging with significant improvement till 2 years post-therapy. We have explored the ambiguity in the current treatment methods in hematopoietic stem cell therapy that needs further exploration to optimize the results out of this treatment modality.