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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Nov 27, 2021; 12(6): 104-113
Published online Nov 27, 2021. doi: 10.4331/wjbc.v12.i6.104
Neuroprotection by dipeptidyl-peptidase-4 inhibitors and glucagon-like peptide-1 analogs via the modulation of AKT-signaling pathway in Alzheimer’s disease
Yuka Ikeda, Nozomi Nagase, Ai Tsuji, Yasuko Kitagishi, Satoru Matsuda
Yuka Ikeda, Nozomi Nagase, Ai Tsuji, Yasuko Kitagishi, Satoru Matsuda, Food Science and Nutrition, Nara Women’s University, Nara 630-8506, Japan
Author contributions: Each author (Ikeda Y, Nagase N, Tsuji A, Kitagishi Y, Matsuda S) participated sufficiently in this work of drafting the article and/or revising the article for the important rational content; all authors gave final approval of the version to be submitted.
Conflict-of-interest statement: The authors declare that they have no competing financial interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Satoru Matsuda, MD, PhD, Professor, Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan. smatsuda@cc.nara-wu.ac.jp
Received: March 26, 2021
Peer-review started: March 26, 2021
First decision: May 6, 2021
Revised: May 21, 2021
Accepted: November 28, 2021
Article in press: November 28, 2021
Published online: November 27, 2021
Processing time: 263 Days and 2.8 Hours
Core Tip

Core Tip: Disorders of mammalian/mechanistic target of rapamycin (mTOR) signaling pathways are related to Alzheimer’s disease (AD). Although further studies for mTOR, glucagon-like peptide-1, and dipeptidyl-peptidase-4 signaling are needed, they seem to be a promising approach for innovative AD-treatments.