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World J Biol Chem. May 26, 2012; 3(5): 93-97
Published online May 26, 2012. doi: 10.4331/wjbc.v3.i5.93
Published online May 26, 2012. doi: 10.4331/wjbc.v3.i5.93
Peroxisomes, oxidative stress, and inflammation
Stanley R Terlecky, Laura J Terlecky, Courtney R Giordano, Department of Pharmacology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, United States
Author contributions: Terlecky SR wrote the majority of the review; Terlecky LJ and Giordano CR contributed to the writing, designed and produced the figures, and edited the manuscript.
Correspondence to: Stanley R Terlecky, PhD, Department of Pharmacology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, United States. srterlecky@med.wayne.edu
Telephone: +1-313-5773557 Fax: +1-313-5776739
Received: July 27, 2011
Revised: May 10, 2012
Accepted: May 17, 2012
Published online: May 26, 2012
Revised: May 10, 2012
Accepted: May 17, 2012
Published online: May 26, 2012
Abstract
Peroxisomes are intracellular organelles mediating a wide variety of biosynthetic and biodegradative reactions. Included among these are the metabolism of hydrogen peroxide and other reactive species, molecules whose levels help define the oxidative state of cells. Loss of oxidative equilibrium in cells of tissues and organs potentiates inflammatory responses which can ultimately trigger human disease. The goal of this article is to review evidence for connections between peroxisome function, oxidative stress, and inflammation in the context of human health and degenerative disease. Dysregulated points in this nexus are identified and potential remedial approaches are presented.
Keywords: Peroxisomes; Oxidative stress; Inflammation