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World J Biol Chem. Jun 26, 2011; 2(6): 132-139
Published online Jun 26, 2011. doi: 10.4331/wjbc.v2.i6.132
Published online Jun 26, 2011. doi: 10.4331/wjbc.v2.i6.132
Ikaros in B cell development and function
MacLean Sellars, New York University School of Medicine, New York, NY 10016, United States
Philippe Kastner, Susan Chan, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 67400, France
Philippe Kastner, Susan Chan, Inserm U964, Illkirch, 67400 France; CNRS UMR 7104, Illkirch, 67400, France
Philippe Kastner, Susan Chan, Université de Strasbourg, Strasbourg, 67000, France
Author contributions: Sellars M wrote the manuscript; Kastner P and Chan S provided support and supervision.
Supported by La Ligue Contre le Cancer (équipe labellisée), l’Agence Nationale de la Recherche and La Fondation pour la Recherche Médicale, with institute funding from INSERM, CNRS and l’Université de Strasbourg
Correspondence to: MacLean Sellars, PhD, New York University School of Medicine, 540 First Avenue, New York, NY 10016, United States. maclean.sellars@nyu.med.edu
Telephone: +1-212-263-6921 Fax: +1-212-263-1498
Received: March 22, 2011
Revised: June 18, 2011
Accepted: June 23, 2011
Published online: June 26, 2011
Revised: June 18, 2011
Accepted: June 23, 2011
Published online: June 26, 2011
Abstract
The zinc finger transcription factor, Ikaros, is a central regulator of hematopoiesis. It is required for the development of the earliest B cell progenitors and at later stages for VDJ recombination and B cell receptor expression. Mature B cells rely on Ikaros to set the activation threshold for various stimuli, and to choose the correct antibody isotype during class switch recombination. Thus, Ikaros contributes to nearly every level of B cell differentiation and function.