Francis OL, Payne JL, Su RJ, Payne KJ. Regulator of myeloid differentiation and function: The secret life of Ikaros. World J Biol Chem 2011; 2(6): 119-125 [PMID: 21765977 DOI: 10.4331/wjbc.v2.i6.119]
Corresponding Author of This Article
Kimberly J Payne, PhD, Assistant Professor, Department of Pathology and Human Anatomy, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Mortensen Hall 1st Floor, 11085 Campus St, Loma Linda, CA 9350, United States. kpayne@llu.edu
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World J Biol Chem. Jun 26, 2011; 2(6): 119-125 Published online Jun 26, 2011. doi: 10.4331/wjbc.v2.i6.119
Regulator of myeloid differentiation and function: The secret life of Ikaros
Olivia L Francis, Jonathon L Payne, Rui-Jun Su, Kimberly J Payne
Olivia L Francis, Rui-Jun Su, Kimberly J Payne, Department of Pathology and Human Anatomy, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Mortensen Hall 1st Floor, 11085 Campus St, Loma Linda, CA 9350, United States
Jonathon L Payne, Department of Chemistry and Biochemistry, La Sierra University, 4500 Riverwalk Parkway, Riverside CA 92515, United States
Author contributions: Francis OL was responsible for the initial review of the literature; Payne JL and Francis OL were responsible for condensing data from the literature review to develop the figures; Su RJ was responsible for critically reviewing and revising the manuscript for intellectual content; Payne KJ prepared the initial draft of the manuscript and edited it for final revisions.
Correspondence to: Kimberly J Payne, PhD, Assistant Professor, Department of Pathology and Human Anatomy, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Mortensen Hall 1st Floor, 11085 Campus St, Loma Linda, CA 9350, United States. kpayne@llu.edu
Received: March 22, 2011 Revised: May 2, 2011 Accepted: May 9, 2011 Published online: June 26, 2011
Abstract
Ikaros (also known as Lyf-1) was initially described as a lymphoid-specific transcription factor. Although Ikaros has been shown to regulate hematopoietic stem cell renewal, as well as the development and function of cells from multiple hematopoietic lineages, including the myeloid lineage, Ikaros has primarily been studied in context of lymphoid development and malignancy. This review focuses on the role of Ikaros in myeloid cells. We address the importance of post-transcriptional regulation of Ikaros function; the emerging role of Ikaros in myeloid malignancy; Ikaros as a regulator of myeloid differentiation and function; and the selective expression of Ikaros isoform-x in cells with myeloid potential. We highlight the challenges of dissecting Ikaros function in lineage commitment decisions among lymphoid-myeloid progenitors that have emerged as a major myeloid differentiation pathway in recent studies, which leads to reconstruction of the traditional map of murine and human hematopoiesis.
