Al-Amrani S, Al-Jabri Z, Al-Zaabi A, Alshekaili J, Al-Khabori M. Proteomics: Concepts and applications in human medicine. World J Biol Chem 2021; 12(5): 57-69 [PMID: 34630910 DOI: 10.4331/wjbc.v12.i5.57]
Corresponding Author of This Article
Murtadha Al-Khabori, BSc, MD, MSc, Associate Professor, Staff Physician, Department of Hematology, Sultan Qaboos University, Al-Khod, Sultan Qaboos University Street, Muscat 123, Oman. khabori@squ.edu.om
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Safa Al-Amrani, Zaaima Al-Jabri, Department of Microbiology and Immunology, Sultan Qaboos University, Muscat 123, Oman
Adhari Al-Zaabi, Department of Human and Clinical Anatomy, Sultan Qaboos University, Muscat 123, Oman
Jalila Alshekaili, Department of Microbiology and Immunology, Sultan Qaboos University Hospital, Muscat 123, Oman
Murtadha Al-Khabori, Department of Hematology, Sultan Qaboos University, Muscat 123, Oman
Author contributions: Al-Amrani S drafted the first draft and approved the final version; Al-Jabri Z, Al-Zaabi A, Alshekaili J, and Al-Khabori M critically edited the manuscript and approved the final version.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Murtadha Al-Khabori, BSc, MD, MSc, Associate Professor, Staff Physician, Department of Hematology, Sultan Qaboos University, Al-Khod, Sultan Qaboos University Street, Muscat 123, Oman. khabori@squ.edu.om
Received: February 22, 2021 Peer-review started: February 22, 2021 First decision: April 20, 2021 Revised: May 4, 2021 Accepted: July 15, 2021 Article in press: July 15, 2021 Published online: September 27, 2021 Processing time: 212 Days and 3.6 Hours
Abstract
Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of their complexity and dynamicity. Therefore, combining the proteomics approach with genomics and bioinformatics will provide an understanding of the information of biological systems and their disease alteration. However, most studies have investigated a small part of the proteins in the blood. This review highlights the types of proteomics, the available proteomic techniques, and their applications in different research fields.
Core Tip: Proteomics is the complete evaluation of the structure and function of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used to profile proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of the complexity and dynamicity. This review highlights the types of proteomics, the available proteomic techniques, and their applications in different research fields.
