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World J Biol Chem. Oct 26, 2010; 1(10): 291-297
Published online Oct 26, 2010. doi: 10.4331/wjbc.v1.i10.291
Published online Oct 26, 2010. doi: 10.4331/wjbc.v1.i10.291
Sphingosine-1-phosphate signaling in vasculogenesis and angiogenesis
Kelley M Argraves, Brent A Wilkerson, W Scott Argraves, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, United States
Author contributions: Argraves KM, Wilkerson BA and Argraves WS wrote and revised the manuscript.
Supported by Grants from the United States Public Health Service/National Institutes of Health, No. HL080404, HL094883 (Argraves KM) and HL061873, HL095067 (Argraves WS); and by NIH Training Grant to Improve Cardiovascular Therapies HL007260 (Wilkerson BA) and American Heart Association 10PRE3910006 (Wilkerson BA)
Correspondence to: Kelley M Argraves, PhD, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, United States. argravek@musc.edu
Telephone: +1-843-7923535 Fax: +1-843-7920664
Received: July 20, 2010
Revised: August 29, 2010
Accepted: September 5, 2010
Published online: October 26, 2010
Revised: August 29, 2010
Accepted: September 5, 2010
Published online: October 26, 2010
Abstract
Blood vessels either form de novo through the process of vasculogenesis or through angiogenesis that involves the sprouting and proliferation of endothelial cells in pre-existing blood vessels. A complex interactive network of signaling cascades downstream from at least three of the nine known G-protein-coupled sphingosine-1-phosphate (S1P) receptors act as a prime effector of neovascularization that occurs in embryonic development and in association with various pathologies. This review focuses on the current knowledge of the roles of S1P signaling in vasculogenesis and angiogenesis, with particular emphasis on vascular cell adhesion and motility responses.
Keywords: Sphingosine-1-phosphate, Vasculogenesis, Angiogenesis, G-protein-coupled receptors, Endothelium