Correlation between abdominal computed tomography signs and postoperative prognosis for patients with colorectal cancer

Table 1 Univariate analysis of postoperative death in patients with colorectal cancer, n (%)

Data		Death group (n = 23)	Survival group (n = 65)	χ2	P value
Gender	Male	14 (60.87)	37 (56.92)	0.109	0.742
	Female	9 (39.13)	28 (43.08)
Age	≥ 60 years	15 (65.22)	36 (55.38)	0.674	0.412
	< 60 years	8 (34.78)	29 (44.62)
BMI	< 18.5 kg/m2	0 (0.00)	4 (6.15)	16.992	< 0.001
	18.5-24 kg/m2	11 (47.83)	55 (84.62)
	> 24 kg/m2	12 (52.17)	6 (9.23)
Smoking history	Yes	9 (39.13)	23 (35.38)	0.103	0.748
	No	14 (60.87)	42 (64.62)
Drinking history	Yes	7 (30.43)	18 (27.69)	0.063	0.802
	No	16 (69.57)	47 (72.31)
Pathological stage	I	0 (0.00)	10 (15.38)	15.401	0.001
	II	7 (30.43)	39 (60.00)
	III	12 (52.17)	13 (20.00)
	IV	4 (17.39)	3 (4.62)
Blood vessel invasion	Yes	1 (4.35)	2 (3.08)	< 0.001	> 0.999
	No	22 (95.65)	63 (96.92)
Degree of tumor differentiation	Poorly differentiated	6 (26.09)	5 (7.69)	8.950	0.011
	Moderately differentiated	16 (69.57)	42 (64.62)
	Highly differentiated	1 (4.35)	18 (27.69)
Lymphatic metastasis	Yes	10 (43.48)	14 (21.54)	4.123	0.042
	No	13 (56.52)	51 (78.46)
Tumor site	Right semicolon	8 (34.78)	12 (18.46)	2.824	0.244
	Left semicolon	5 (21.74)	14 (21.54)
	Rectum	10 (43.48)	39 (60.00)
Intestinal wall thickening form	Polyps or cauliflower thickening	6 (26.09)	9 (13.85)	2.201	0.532
	Eccentric thickening	9 (39.13)	28 (43.08)
	Uneven ring thickening	6 (26.09)	24 (36.92)
	Uniform ring thickening	2 (8.70)	4 (6.15)
Degree of periintestinal infiltration	Mild	0 (0.00)	33 (50.77)	48.385	< 0.001
	Moderate	4 (17.39)	27 (41.54)
	Severe	19 (82.61)	5 (7.69)
Transformation rate of signal	Mild	8 (34.78)	22 (33.85)	2.879	0.237
	Moderate	6 (26.09)	28 (43.08)
	Severe	9 (39.13)	15 (23.08)
Low-density area after enhancement	Yes	13 (56.52)	40 (61.54)	0.178	0.673
	No	10 (43.48)	25 (38.46)
Lymph node location	Mesenterium	15 (65.22)	36 (55.38)	1.234	0.540
	Root	7 (30.43)	22 (33.85)
	Lateral	1 (4.35)	7 (10.77)
Tumor size	< 4 cm	4 (17.39)	38 (58.46)	11.486	0.001
	≥ 4 cm	19 (82.61)	27 (41.54)
Lymph node CT value	< 30 HU	4 (17.39)	39 (60.00)	10.697	0.001
	≥ 30 HU	19 (82.61)	26 (40.00)
Mean tumor long-axis diameter	< 0.6 cm	4 (17.39)	35 (53.85)	7.731	0.005
	≥ 0.6 cm	19 (82.61)	30 (46.15)
Mean tumor short-axis diameter	< 0.45 cm	5 (21.74)	36 (55.38)	7.729	0.005
	≥ 0.45 cm	18 (78.26)	29 (44.62)

BMI: Body mass index; CT: Computed tomography.

Table 2 Assignment table

Independent variable	Assignment
BMI	0: < 18.5 kg/m2; 1: 18.5-24 kg/m2; 2: > 24 kg/m2
Pathological stage	1: I; 2: II; 3: III; 4: IV
Degree of tumor differentiation	1: Poorly differentiated; 2: Moderately differentiated; 3: Highly differentiated
Degree of periintestinal infiltration	1: Mild; 2: Moderate; 3: Severe
Tumor size	0: < 4 cm; 1: ≥ 4 cm
Lymph node CT value	0: < 30 HU; 1: ≥ 30 HU
Mean tumor long-axis diameter	0: < 0.6 cm; 1: ≥ 0.6 cm
Mean tumor short-axis diameter	0: < 0.45 cm; 1: ≥ 0.45 cm

BMI: Body mass index; CT: Computed tomography.

Table 3 Multivariate Cox regression analysis of postoperative death in patients with colorectal cancer

Independent variable	B	SE	Wald	P value	OR	95%CI
BMI	0.409	0.139	8.621	0.003	1.506	1.146-1.979
Pathological stage			2.255	0.521
I	-7.741	222.369	0.001	0.972	0.000	0.000-8.303
II	0.957	0.780	1.504	0.220	2.603	0.564-12.003
III	1.052	0.712	2.183	0.140	2.865	0.709-11.569
Degree of tumor differentiation			1.749	0.417
Poorly differentiated	0.686	1.290	0.283	0.595	1.986	0.158-24.909
Moderately differentiated	-0.302	1.114	0.074	0.786	0.739	0.083-6.565
Degree of periintestinal infiltration			7.030	0.030
Mild	-12.450	167.468	0.006	0.941	0.000	0.000-1.390
Moderate	-1.784	0.673	7.025	0.008	0.168	0.045-0.628
Tumor size	1.522	0.660	5.322	0.021	4.581	1.257-16.691
Lymph node CT value	1.362	0.689	3.911	0.048	3.904	1.012-15.059
Mean tumor long-axis diameter	0.918	0.809	1.287	0.257	2.505	0.513-12.240

BMI: Body mass index; CT: Computed tomography; B: Regression coefficient β; SE: Standard error; OR: Odds ratio; CI: Confidence interval.

Table 4 Receiver operating characteristic analysis

Variable	Area (95%CI)	Standard error	P value	Sensitivity	Specificity
BMI	0.847 (0.753-0.942)	0.048	< 0.001	82.6%	83.1%
Degree of periintestinal infiltration	0.735 (0.613-0.857)	0.062	0.001	52.2%	86.2%
Tumor size	0.705 (0.587-0.824)	0.06	0.004	82.6%	58.5%
Lymph node CT value	0.648 (0.518-0.778)	0.066	0.036	69.6%	60.0%

BMI: Body mass index; CT: Computed tomography; CI: Confidence interval.

Table 5 Correlation between postoperative survival time and abdominal computed tomography signs in patients with colorectal cancer

Independent variable		Survival time	BMI	Degree of periintestinal infiltration	Tumor size	Lymph nodes CT value	Mean tumor long-axis diameter	Mean tumor short-axis diameter
Survival time	r value	-	-0.559	-0.679	-0.430	-0.585	-0.425	-0.385
	P value	-	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
BMI	r value	-	-	0.303	0.254	0.431	0.211	0.437
	P value	-	-	0.004	0.017	< 0.001	0.049	< 0.001
Degree of periintestinal infiltration	r value	-	-	-	0.199	0.246	0.332	0.264
	P value	-	-	-	0.063	0.021	0.002	0.013
Tumor size	r value	-	-	-	-	0.352	0.303	0.276
	P value	-	-	-	-	0.001	0.004	0.009
Lymph node CT value	r value	-	-	-	-	-	0.390	0.420
	P value	-	-	-	-	-	< 0.001	< 0.001
Mean tumor long-axis diameter	r value	-	-	-	-	-	-	0.587
	P value	-	-	-	-	-	-	< 0.001
Mean tumor short-axis diameter	r value	-	-	-	-	-	-	-
	P value	-	-	-	-	-	-	-

BMI: Body mass index; CT: Computed tomography.