Immune function status of postoperative patients with colon cancer for predicting liver metastasis

Table 1 Comparison of baseline data and laboratory indicators of patients between the two groups

Data		Occurrence group (n = 100)	Non-occurrence group (n = 100)	Statistical values	P value
Sex	Male	61 (61.00)	58 (58.00)	χ2 = 0.187	0.666
	Female	39 (39.00)	42 (42.00)
Age		63.02 ± 3.88 (49-71)	62.25 ± 3.75 (53-71)	t = 1.427	0.155
Tumor site	Right hemicolon	40 (40.00)	45 (45.00)	χ2 = 0.512	0.475
	Left hemicolon	60 (60.00)	55 (55.00)
Tumor typing	Infiltration type	22 (22.00)	30 (30.00)	χ2 = 0.189	0.389
	Ulcer type	35 (35.00)	30 (30.00)
	Uplift type	45 (45.00)	40 (40.00)
CEA (μg/L)		8.95 ± 1.30	5.25 ± 1.52	t = 18.499	< 0.001
CA19-9 (IU/mL)		42.25 ± 8.25	22.56 ± 4.58	t = 20.867	< 0.001
CA242 (U/mL)		142.25 ± 20.52	85.65 ± 15.05	t = 17.055	< 0.001
CA72-4 (U/mL)		55.85 ± 10.58	23.25 ± 5.28	t = 27.570	< 0.001
CA50 (U/mL)		42.25 ± 6.25	32.15 ± 4.20	t = 13.413	< 0.001
CD3+ (%)		53.45 ± 5.52	67.50 ± 8.40	t = 13.978	< 0.001
CD4+ (%)		26.58 ± 3.45	37.35 ± 4.10	t = 20.100	< 0.001
CD8+ (%)		24.52 ± 4.10	33.02 ± 6.50	t = 11.060	< 0.001
NK (%)		31.25 ± 3.85	45.20 ± 5.15	t = 21.695	< 0.001
CD4+/CD25 (%)		5.10 ± 2.15	9.52 ± 3.56	t = 10.628	< 0.001

CEA: Carcinoembryonic antigen; NK: Natural killer.

Table 2 Logistic regression analysis of the relationship between immune-related indicators, tumor-related indicators, and liver metastasis in colon cancer

Variable	B	SE	Walls	P value	OR value	95% confidence interval
						Upper limit	Lower limit
Constant	-14.183	2.230	40.440	< 0.001	0.000	-	-
CEA	1.953	0.299	42.755	< 0.001	7.051	3.926	12.662
CA19-9	0.483	0.081	35.206	< 0.001	1.620	1.382	1.900
CA242	0.163	0.027	37.738	< 0.001	1.177	1.117	1.240
CA72-4	0.630	0.178	12.509	< 0.001	1.878	1.324	2.662
CA50	0.367	0.051	51.721	< 0.001	1.443	1.306	1.595
CD3+	0.318	0.045	49.250	< 0.001	1.374	1.258	1.502
CD4+	0.85	0.127	40.082	< 0.001	2.236	1.743	2.869
CD8+	0.255	0.084	9.257	< 0.001	1.291	1.095	1.521
NK	0.582	0.111	27.604	< 0.001	1.790	1.440	2.224
CD4+/CD25	0.476	0.091	27.525	< 0.001	1.610	1.348	1.923

OR: Odds ratio; CEA: Carcinoembryonic antigen; NK: Natural killer.

Table 3 Efficacy analysis of the relationship between immune-related and tumor-related indicators in predicting liver metastasis in colon cancer

Indicator	AUC	95% CI for AUC	Standard error	P value	Cut-off value	Sensitivity	Specificity
CEA	0.956	0.927-0.984	0.014	< 0.001	4.170	0.990	0.770
CA19-9	0.986	0.972-1.000	0.007	< 0.001	21.820	0.990	0.640
CA242	0.987	0.976-1.000	0.006	< 0.001	89.915	0.990	0.420
CA72-4	0.990	0.976-1.000	0.007	< 0.001	28.625	0.990	0.150
CA50	0.912	0.872-0.952	0.020	< 0.001	28.985	0.990	0.780
CD3+	0.912	0.870-0.954	0.021	< 0.001	46.925	0.990	0.900
CD4+	0.978	0.962-0.995	0.008	< 0.001	26.725	0.990	0.480
CD8+	0.869	0.820-0.917	0.025	< 0.001	19.290	0.990	0.900
NK	0.980	0.965-0.995	0.008	< 0.001	32.430	0.990	0.370
CD4+/CD25	0.870	0.818-0.922	0.027	< 0.001	0.015	0.990	0.990

AUC: Area under curve; CEA: Carcinoembryonic antigen; NK: Natural killer.