Preoperative blood markers and intra-abdominal infection after colorectal cancer resection

Table 1 Comparison of general information between the patient groups

	IAI group (%)	Non-IAI group (%)	t/χ2	P value
Sample size	15	65	–	–
Gender
Male	11 (73.3)	35 (53.8)	1.894	0.169
Female	4 (26.7)	30 (46.2)
Age	65.63 ± 13.03	57.75 ± 12.86	-2.119	0.046
BMI	24.05 ± 3.47	22.94 ± 2.99	-1.257	0.212
Smoking history
Yes	6 (40.0)	20 (30.8)	0.473	0.491
No	9 (60.0)	45 (69.2)
Hypertension
Yes	10 (66.7)	33 (50.8)	1.239	0.266
No	5 (33.3)	32 (49.2)
Diabetes
Yes	8 (53.3)	38 (58.5)	0.131	0.717
No	7 (46.7)	27 (41.5)
Preoperative anemia
Yes	12 (80.0)	47 (72.3)	0.373	0.542
No	3 (20.0)	18 (27.7)
Tumor site
Left	8 (53.3)	37 (56.9)	0.064	0.801
Right	7 (46.7)	28 (43.1)
Degree of differentiation
Medium and above	9 (60.0)	30 (46.2)	0.935	0.334
Low	6 (40.0)	35 (53.8)
Infiltration depth
T3 + T4	8 (53.3)	38 (58.5)	0.131	0.717
T1 + T2	7 (46.7)	27 (41.5)
Tumor diameter (cm)	4.69 ± 1.15	4.79 ± 1.21	0.293	0.770
Lymphatic metastasis
Yes	6 (40.0)	23 (35.4)	0.112	0.737
No	9 (60.0)	42 (64.6)
Gross classification of tumor
Ulcerative	4 (26.7)	13 (20.0)	0.500	0.868
Wettability	7 (46.7)	31 (47.7)
Uplift type	4 (26.7)	21 (32.3)
Intraoperative bleeding	388.58 ± 59.27	402.23 ± 57.11	0.810	0.428

IAI: Intra-abdominal infection, BMI: Body mass index.

Table 2 Comparison of laboratory indexes between the patient groups

Project	IAI group	Non-IAI group	t	P value
HGB (g/L)	126.74 ± 19.58	130.29 ± 21.13	0.595	0.554
RBC (1012/L)	4.09 ± 0.32	4.06 ± 0.28	-0.267	0.790
ALB (g/L)	38.19 ± 2.13	38.11 ± 2.31	-0.131	0.896
WBC (109/L)	5.63 ± 1.03	5.46 ± 0.87	-0.657	0.513
PLT (109/L)	359.33 ± 30.33	291.41 ± 63.94	-3.997	0.000
NE (109/L)	4.84 ± 0.70	3.44 ± 1.11	-4.684	0.000
LY (109/L)	1.44 ± 0.18	1.73 ± 0.34	3.174	0.002
CD45+ CD3-	13.41 ± 0.87	14.46 ± 1.55	2.518	0.014
CD4/CD8	1.49 ± 0.092	1.49 ± 0.11	0.137	0.891
NLR	3.43 ± 0.65	2.08 ± 0.84	-5.770	0.000
PLR	253.87 ± 40.95	177.65 ± 62.28	-4.508	0.000
SII	1226.48 ± 245.55	611.52 ± 285.96	-7.691	0.000
CEA (μg/L)	4.32 ± 0.65	3.65 ± 0.84	-2.913	0.005
AFP (μg/L)	3.63 ± 0.94	3.57 ± 0.91	-0.218	0.829
SCC (μg/L)	1.40 ± 0.086	1.40 ± 0.097	0.038	0.970
CA19-9 (Ku/L)	18.78 ± 0.75	18.84 ± 1.24	0.169	0.866
CA-125 (Ku/L)	10.64 ± 1.04	11.13 ± 1.09	1.576	0.119
CA15-3 (Ku/L)	8.26 ± 1.06	7.87 ± 0.96	-1.378	0.172
Hsp90α (ng/mL)	38.21 ± 2.82	38.49 ± 2.69	0.344	0.734

IAI: Intra-abdominal infection; HGB: Hemoglobin; RBC: Red Blood Cell; ALB: Albumin; WBC: White blood cell; PLT: Platelet; NE: Neutrophilicgranulocyte; LY: Lymphocyte; CD45+ CD3-: Cluster of differentiation 45+ cluster of differentiation 3-; CD4/CD8: Cluster of differentiation 4/cluster of differentiation 8; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; SII: Systemic immune-inflammation index; CEA: Carcinoembryonic antigen; AFP: Alpha-fetopro-tei; SCC: Squamous cell carcinoma antigen; CA19-9: Carbohydrate Antigen 19-9; CA-125: Carbohydrate Antigen 125; CA15-3: Carbohydrate Antigen 15-3; Hsp90α: Heat Shock Protein 90 α.

Table 3 Multivariate analysis of intra-abdominal infection in patients that underwent radical resection of colorectal cancer

Independent variable	B	S.E.	Wald	P value	OR	95%CI
Age	0.001	0.055	0.000	0.990	1.001	0.899-1.114
CD45+ CD3-	0.355	1.185	0.090	0.765	1.426	0.140-14.542
NLR	-1.615	0.677	5.69	0.017	1.199	0.053-1.750
PLR	-0.022	0.010	5.13	0.024	1.978	0.960-1.997
SII	0.010	0.004	7.194	0.007	1.010	1.003-1.018
CEA (μg/L)	3.131	1.414	4.903	0.027	22.905	1.433-366.157
Constant	-20.789	18.767	1.227	0.268	0.000	–

CD45+ CD3-: Cluster of differentiation 45+ cluster of differentiation 3-; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; SII: Systemic immune-inflammation index; CEA: Carcinoembryonic antigen; CI: Confidence interval; OR: Odds ratio.

Table 4 Diagnostic value of receiver operating characteristic curve evaluation index

Independent variable	Cutoff	AUC	Sensitivity	Specificity	Youden index	P value	95%CI
NLR	2.67	0.890	0.867	0.800	0.667	0.000	0.811-0.969
PLR	213.18	0.842	0.933	0.723	0.656	0.000	0.757-0.927
SII	826.24	0.937	0.215	0.785	0.785	0.000	0.886-0.989
CEA (μg/L)	4.03	0.728	0.667	0.708	0.375	0.006	0.595-0.861

NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; SII: Systemic immune-inflammation index; CEA: Carcinoembryonic antigen; AUC: Area under the curve.