Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Feb 27, 2024; 16(2): 451-462
Published online Feb 27, 2024. doi: 10.4240/wjgs.v16.i2.451
Preoperative blood markers and intra-abdominal infection after colorectal cancer resection
Chang-Qing Liu, Zhong-Bei Yu, Jin-Xian Gan, Tian-Ming Mei
Chang-Qing Liu, Zhong-Bei Yu, Jin-Xian Gan, Tian-Ming Mei, Department of Gastrointestinal Anorectal Surgery, Suzhou Hospital Affiliated to Anhui Medical University, Suzhou 234000, Anhui Province, China
Author contributions: Liu CQ designed and performed the study and wrote the paper; Mei TM designed the study and supervised the report; Gan JX collected the data and contributed to the analysis; Yu ZB provided clinical advice.
Supported by Suzhou Health Scientific Research Project, No. SZWJ2022a001.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Suzhou Hospital affiliated to Anhui Medical University.
Informed consent statement: The Ethics Committee has waived informed consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tian-Ming Mei, MBBS, Chief Physician, Department of Gastrointestinal Anorectal Surgery, Suzhou Hospital Affiliated to Anhui Medical University, No. 616 Bianyang Third Road, Yongqiao District, Suzhou 234000, Anhui Province, China. mtm19871018@126.com
Received: November 21, 2023
Peer-review started: November 21, 2023
First decision: December 5, 2023
Revised: December 16, 2023
Accepted: January 23, 2024
Article in press: January 23, 2024
Published online: February 27, 2024
Processing time: 96 Days and 6.6 Hours
ARTICLE HIGHLIGHTS
Research background

Postoperative complications are important clinical outcomes in patients with colorectal cancer (CRC). Abdominal infection is a serious complication of radical resection of CRC. Currently, the risk factors for abdominal infections after CRC surgery are unclear.

Research motivation

To explore the correlation between inflammatory indicators and abdominal infection in patients after radical resection of CRC and construct a risk prediction model to provide a theoretical basis for prevention and intervention.

Research objectives

To explore the predictive value of preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and carcinoembryonic antigen (CEA) levels for intra-abdominal infection (IAI) in patients after radical resection of CRC and provide an evaluation tool for individualized treatment of patients.

Research methods

This study was based on a retrospective analysis of the preoperative NLR, PLR, SII, and CEA levels in 80 patients who were admitted and underwent radical resection of CRC. A risk prediction model was constructed and verified.

Research result

Studies have shown that the NLR, PLR, SII, and CEA are risk factors for IAI in patients with CRC after radical surgery. The area under the curve of the training set (n = 60) for the nomogram prediction model was 0.968 [95% confidence interval (CI): 0.948-0.988], and that of the validation set (n = 20) was 0.926 (95%CI: 0.906-0.980). Calibration curves of the training and validation sets showed that the predicted results corresponded with the observed results. decision curve analysis curve analysis showed that patients with CRC could benefit from the prediction model.

Research conclusions

A nomogram combining the NLR, PLR, SII, and CEA levels was established. It has good accuracy and reliability in predicting abdominal infections in patients after radical resection of CRC, which is helpful in clinical treatment decision-making and has clinical significance in improving the prognosis of patients.

Research perspectives

Based on the general data and laboratory indicators of patients undergoing radical resection of CRC, we observed whether IAI occurred and focused on the analysis of preoperative NLR, PLR, SII, and CEA levels and the construction of relevant prediction models.