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©The Author(s) 2023.
World J Gastrointest Surg. Feb 27, 2023; 15(2): 273-286
Published online Feb 27, 2023. doi: 10.4240/wjgs.v15.i2.273
Published online Feb 27, 2023. doi: 10.4240/wjgs.v15.i2.273
Table 1 Basic characteristics of included studies, hepatocellular carcinoma < 10 cm
| Study | Year | Follow-up, mo | No. | Age, yr | Sex (M/F) | Tumour size, cm | Cirrhosis, n (%) | Child-Pugh class, n (%) | |
| A | B + C | ||||||||
| Allemann et al[15] | 2013 | 25 | 79 | 67 (21-85) | NA | 4.9 (1-9) | 61 (77) | 75 (95) | 4 (5) |
| Chang et al[21] | 2016 | 72.5 | 10167 | NA | 7618/2711 | NA | 1114 (11) | NA | NA |
| Choi et al[22] | 2009 | 36 | 447 | 53.3 (9.7) | 344/103 | NA | 244 (55) | 443 (99) | 4 (1) |
| Fang et al[16] | 2019 | 20 | 104 | NA | 85/19 | NA | 93 (89) | 101 (97) | 3 (3) |
| Giuliante et al[23] | 2013 | NA | 28 | 65.8 (8.8) | 22/6 | 7.9 (7-8.1) | NA | 28 (100) | 0 (0) |
| Huang et al[24] | 2016 | 26 | 272 | NA | 242/30 | NA | 90 (82) | NA | NA |
| Jo et al[25] | 2011 | 30 | 40 | 54.6 (10.5) | 36/4 | 3.81 (2.06) | NA | 35 (88) | 5 (13) |
| Lee et al[17] | 2021 | NA | 3559 | 59.1 (12.1) | 2716/843 | 3.36 (2.14) | NA | NA | NA |
| Lewis et al[26] | 2019 | 22 | 26 | NA | NA | NA | NA | NA | NA |
| Liau et al[27] | 2005 | 27 | 111 | 63.0 (12.0) | 80/31 | 6.1 (2.5) | 40 (36) | 104 (94) | 7 (6) |
| Nagano et al[28] | 2005 | NA | 143 | 62.0 (9.0) | 112/31 | 3.25 (1.2-9.5) | 81 (57) | 101 (71) | NA |
| Noh et al[14] | 2016 | 26.4 | 73 | 56.85 (10.7) | 56/17 | NA | NA | NA | NA |
| Poon et al[29] | 2002 | 56 | 368 | 54.1 (12.2) | 295/73 | 5.4 (2.6) | 203 (55) | NA | NA |
| Shah et al[30] | 2007 | 34 | 165 | 62.0 (14.0) | NA | 4.7 (2.2) | NA | 145 (88) | 14 (8) |
| Tanaka et al[31] | 2015 | 39 | 291 | 67 (61-73) | 220/71 | 4 (2.3 – 5) | 134 (46) | 270 (93) | 21 (7) |
| Taniai et al[32] | 2008 | 22.5 | 291 | 64.1 (8.7) | 225/66 | 3.71 (1.91) | 156 (54) | 209 (72) | 82 (28) |
| Thng et al[33] | 2015 | 22 | 63 | 59 (27-81) | 50/13 | NA | NA | 60 (95) | 3 (5) |
| Wakayama et al[34] | 2017 | 57 | 521 | 62.8 (10.1) | 427/94 | 4 (2.1) | NA | 511 (98) | 8 (2) |
| Yamashita et al[35] | 2011 | NA | 412 | 64.0 (3.0) | 328/84 | 3.8 (2.2) | NA | 246 (60) | 166 (40) |
| Yang et al[37] | 2013 | NA | 293 | 47.0 (13.0) | 263/57 | 6.7 (3.8) | 201 (69) | 231 (79) | 62 (21) |
| Yang et al[36] | 2014 | NA | 781 | NA | 635/146 | NA | NA | 768 (98) | 51 (7) |
| Yeh et al[38] | 2003 | 16.4 | 985 | 55.7 (13.11) | 776/209 | 4.5 (2.4) | NA | NA | NA |
| Zhong et al[39] | 2017 | NA | 707 | NA | 612/95 | NA | 520 (74) | 672 (95) | 35 (5) |
| Zhu et al[40] | 2015 | 29.4 | 495 | 50.3 (11.2) | 436/59 | 4.8 (2.3) | 129 (26) | 431 (87) | 64 (13) |
Table 2 Basic characteristics of included studies, hepatocellular carcinoma ≥ 10 cm
| Study | Year | Follow-up, mo | No. | Age, yr | Sex (M/F) | Tumour size, cm | Cirrhosis, n (%) | Child-Pugh class, n (%) | |
| A | B + C | ||||||||
| Allemann et al[15] | 2013 | 25 | 22 | 72 (36-88) | NA | 13.5 (10-21) | 9 (41) | 22 (100) | 0 (0) |
| Chang et al[21] | 2016 | 72.5 | 912 | NA | 740/162 | NA | 166 (18) | NA | NA |
| Choi et al[22] | 2009 | 36 | 50 | 50.8 (12.5) | 34/16 | NA | 13 (26) | 48 (96) | 2 (4) |
| Fang et al[16] | 2019 | 20 | 84 | NA | 76/8 | NA | 72 (86) | 77 (92) | 7 (8) |
| Giuliante et al[23] | 2013 | NA | 37 | 62.2 (11) | 28/9 | 12 (11-15) | NA | 36 (97) | 1 (3) |
| Huang et al[24] | 2016 | 26 | 127 | NA | 114/13 | NA | 90 (71) | NA | NA |
| Jo et al[25] | 2011 | 30 | 11 | 52.4 (8.4) | 6/5 | 14.5 (4.11) | NA | 11 (100) | 0 (0) |
| Lee et al[17] | 2021 | NA | 426 | 55.7 (14.3) | 345/81 | 13.14 (4.95) | NA | NA | NA |
| Lewis et al[26] | 2019 | 22 | 16 | NA | NA | NA | NA | NA | NA |
| Liau et al[27] | 2005 | 27 | 82 | 62.0 (14.0) | 48/34 | 14.7 (4.1) | 8 (10) | 73 (89) | 5 (6) |
| Nagano et al[28] | 2005 | NA | 26 | 56.2 (12.2) | 19/7 | 14.8 (10-30) | 5 (19) | 22 (85) | NA |
| Noh et al[14] | 2016 | 26.4 | 41 | 55.1 (10.8) | 33/8 | NA | NA | NA | NA |
| Poon et al[29] | 2002 | 56 | 120 | 50.9 (12.8) | 99/21 | 13.8 (3) | 32 (27) | NA | NA |
| Shah et al[30] | 2007 | 34 | 24 | 57.0 (15.0) | NA | 13.1 (2.9) | NA | 24 (100) | 0 (0) |
| Tanaka et al[31] | 2015 | 39 | 24 | 64.5 (54-71) | 20/4 | 13 (11.2-14.1) | 7 (29) | 20 (83) | 1 (4) |
| Taniai et al[32] | 2008 | 22.5 | 29 | 62.0 (9.4) | 26/3 | 13.45 (2.77) | 12 (41) | 23 (79) | 6 (21) |
| Thng et al[33] | 2015 | 22 | 23 | 63 (34-84) | 20/3 | NA | NA | 20 (87) | 3 (13) |
| Wakayama et al[34] | 2017 | 57 | 54 | 63.9 (12.7) | 43/10 | 12.4 (3.7) | NA | 49 (92) | 4 (8) |
| Yamashita et al[35] | 2011 | NA | 53 | 60.0 (2.0) | 48/5 | 13.2 (0.4) | NA | 38 (72) | 15 (28) |
| Yang et al[37] | 2013 | NA | 258 | 45.0 (12) | 212/46 | 13.2 (4.1) | 171 (66) | 217 (84) | 41 (16) |
| Yang et al[36] | 2014 | NA | 304 | NA | 242/62 | NA | NA | 250 (83) | 16 (5) |
| Yeh et al[38] | 2003 | 16.4 | 211 | 47.8 (13.4) | 164/74 | 13.9 (3.4) | NA | NA | NA |
| Zhong et al[39] | 2017 | NA | 150 | 47.3 (10.9) | 123/27 | 12.4 (2.5) | 88 (59) | 142 (95) | 8 (5) |
| Zhu et al[40] | 2015 | 29.4 | 244 | 46.8 (11.3) | 209/35 | 12 (2.3) | 67 (27) | 210 (86) | 34 (14) |
Table 3 Comparison of tumor characteristics and liver function
| Factor | OR | 95%CI | P value |
| Vascular invasion | 0.367 | 0.236-0.572 | < 0.0001 |
| Multinodular | 0.592 | 0.374-0.939 | 0.0259 |
| Child-Pugh score | 1.008 | 0.745-1.364 | 0.9592 |
| Cirrhosis | 1.955 | 1.317-2.903 | 0.0009 |
- Citation: Lee AJ, Wu AG, Yew KC, Shelat VG. Does size matter for resection of giant versus non-giant hepatocellular carcinoma? A meta-analysis. World J Gastrointest Surg 2023; 15(2): 273-286
- URL: https://www.wjgnet.com/1948-9366/full/v15/i2/273.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v15.i2.273