Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Feb 27, 2023; 15(2): 273-286
Published online Feb 27, 2023. doi: 10.4240/wjgs.v15.i2.273
Does size matter for resection of giant versus non-giant hepatocellular carcinoma? A meta-analysis
Aaron JL Lee, Andrew GR Wu, Kuo Chao Yew, Vishal G Shelat
Aaron JL Lee, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore
Andrew GR Wu, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
Kuo Chao Yew, Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, Singapore 308433, Singapore
Vishal G Shelat, Department of Hepato-Pancreatico-Biliary Surgery, Tan Tok Seng Hospital, Singapore 308433, Singapore
Author contributions: Lee AJ, Wu AG, Yew KC, Shelat VG confirm contribution to study conception and design; Lee AJ, Wu AG contributed to data collection; Lee AJ, Wu AG contributed to analysis and interpretation of results; Lee AJ, Wu AG, Yew KC, Shelat VG contributed to draft manuscript preparation; All authors reviewed the results and approved the final version of the manuscript
Conflict-of-interest statement: The authors declare that they have no affiliations with or involvement in any organization or entity with any financial interests in the subject matter or materials discussed in this manuscript.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Aaron JL Lee, MBBS, Doctor, Lee Kong Chian School of Medicine, Nanyang Technological University, No. 11 Mandalay Rd, Singapore 308232, Singapore. alee047@e.ntu.edu.sg
Received: October 11, 2022
Peer-review started: October 11, 2022
First decision: November 6, 2022
Revised: November 19, 2022
Accepted: February 1, 2023
Article in press: February 1, 2023
Published online: February 27, 2023
Processing time: 139 Days and 9.5 Hours
Core Tip

Core Tip: Resection of giant hepatocellular carcinoma (HCC) is associated with poorer long-term outcomes, with a safety profile similar to that of resection of non-giant HCC. The importance of this is that HCC staging systems should account for the size differences.