Hot topics in pancreatic cancer management

Table 1 Most relevant topics in pancreatic ductal adenocarcinoma management with their current challenges and potential further perspectives

Topic	Challenges	Potential further perspectives
Prevention and early detection	Identification of high risk subjects	Nanotechnology
	Identification of novel biomarkers and signatures that satisfy the WHO REASSURED criteria	Omics technologies
Surgical treatment	Reduction of morbidity and mortality rates	Optimization of vascular resection in high skilled hospitals
Neoadjuvant treatments	Reduction of toxicity	Careful selection of fit patients
		Identification of therapeutic regimens with favorable balance between efficacy and toxicity
Adjuvant treatments	Improvement of oncological outcomes	Targeted therapies
	Significant reduction of toxicity	Immunotherapy
Biology and behavior	Lack of patient models of the tumor in order to improve translational medicine	Organoid ex vivo models

REASSURED: Real Time Connectivity-Ease of specimen collection-Affordable- Sensitive-Specific-User Friendly-Rapid-Equipment Free and Delivered; WHO: World Health Organization.