Caputo D. Hot topics in pancreatic cancer management. World J Gastrointest Surg 2023; 15(2): 121-126 [PMID: 36896312 DOI: 10.4240/wjgs.v15.i2.121]
Corresponding Author of This Article
Damiano Caputo, FACS, MD, Associate Professor, Department of General Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, Rome 00128, Italy. d.caputo@policlinicocampus.it
Research Domain of This Article
Surgery
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Feb 27, 2023; 15(2): 121-126 Published online Feb 27, 2023. doi: 10.4240/wjgs.v15.i2.121
Hot topics in pancreatic cancer management
Damiano Caputo
Damiano Caputo, Department of General Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome 00128, Italy
Damiano Caputo, General Surgery Research Unit, University Campus Bio-Medico di Roma, Rome 00128, Italy
Author contributions: Caputo D finished the concept, writing and critical analysis of this manuscript.
Conflict-of-interest statement: The author declares that he has no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Damiano Caputo, FACS, MD, Associate Professor, Department of General Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, Rome 00128, Italy. d.caputo@policlinicocampus.it
Received: August 27, 2022 Peer-review started: August 27, 2022 First decision: October 21, 2022 Revised: October 27, 2022 Accepted: January 17, 2023 Article in press: January 17, 2023 Published online: February 27, 2023
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a sneaky and lethal disease burdened by poor prognosis. PDAC is often detected too late to be successfully cured, and it has been estimated that it will be a leading cause of cancer-related deaths in the near future. During the last decade, multimodal treatments involving surgery, chemotherapy and radiotherapy have contributed to improving the prognosis of this disease; however, long-term results are still not satisfactory. Postoperative morbidity and mortality rates remain high, and systemic treatments are burdened by toxicity in both neoadjuvant and adjuvant settings. Advancements in technologies, targeted therapies, immunotherapy and PDAC microenvironment modulation strategies may represent useful potential weapons in the future. Nevertheless, in the fight against this dreadful disease, there is an urgent need for new, cheap and user-friendly tools for early detection. In this field, promising results have been found in nanotechnologies and “omics” analyses that search for new biomarkers to be used in primary and secondary prevention. However, there are many issues that need to be solved before considering these tools in daily clinical practice. This editorial reported the state of the art of pancreatic cancer management.
Core Tip: The purpose of this editorial was to provide an up-to-date summary of pancreatic cancer management. The current state of multimodal therapies and the increasingly urgent need for development of tools for early diagnosis were summarized. The editorial also presented the high quality papers in the fields of basic, clinical, preventive and translational medicine that will help further investigations focused on this topic.
