Jiang L, Xu LL, Lu Y, Gu KF, Qian SY, Wang XP, Xu X. Effects and mechanisms of nutritional interventions on extradigestive complications in obese patients. World J Gastrointest Surg 2023; 15(11): 2482-2489 [PMID: 38111757 DOI: 10.4240/wjgs.v15.i11.2482]
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Table 2 Post-intervention changes in the blood pressure between the intervention and control groups (mean ± SE)
Norm
Control subjects
Intervention group
P value
DBP (mmHg)
Start of intervention
86.4 ± 1.4
83.9 ± 1.7
0.241
End of intervention
82.8 ± 1.6
76.6 ± 1.6
0.007
Amount of change before and after intervention
3.6 ± 1.1
7.3 ± 1.1
0.000
SBP (mmHg)
Start of intervention
137.3 ± 1.4
133.2 ± 1.1
0.021
End of intervention
131.1 ± 1.6
116.3 ± 1.5
0.000
Amount of change before and after intervention
6.2 ± 2.0
16.9 ± 1.4
0.022
Table 3 Nutrient intake in the control and intervention groups (mean ± SE)
Original proposal
Control subjects
Intervention group
P value
Energy (kcal)
2033.74 ± 19.45
1953.01 ± 18.55
0.036
Fat (g)
94.21 ± 1.13
50.79 ± 0.75
0.001
Protein (g)
76.42 ± 0.97
97.72 ± 0.89
0.017
Carbohydrates (g)
226.79 ± 3.29
275.03 ± 4.21
0.029
Dietary fiber (g)
10.28 ± 0.11
25.22 ± 1.59
0.005
Cholesterol (mg)
554.96 ± 3.84
473.30 ± 7.33
0.012
SFA (g)
47.58 ± 1.21
27.83 ± 0.28
0.006
MUFA (g)
29.5 ± 0.37
12.44 ± 0.10
0.001
PUFA (g)
20.20 ± 0.21
12.34 ± 0.28
0.013
Sodium (mg)
4347.28 ± 46.34
2284.86 ± 12.43
0.001
Potassium (mg)
1663.15 ± 11.14
3088.78 ± 67.37
0.001
Calcium (mg)
483.84 ± 14.09
864.32 ± 21.60
0.001
Magnesium (mg)
259.97 ± 2.28
479.05 ± 14.12
0.014
Table 4 Comparison of the levels of oxidative stress indicators between the intervention and control groups (mean ± SE)
Norm
Control subjects
Intervention group
P value
ALT (nmol/L)
End of intervention
115.29 ± 1.2
63.94 ± 1.4
0.001
Amount of change before and after intervention
21.25 ± 0.2
20.6 ± 0.1
0.015
AST (μmol/L)
End of intervention
157.15 ± 3.5
59.00 ± 2.8
0.017
Amount of change before and after intervention
20.6 ± 0.2
22.17 ± 0.1
0.021
Table 5 Logistic multifactorial regression analysis of factors affecting the occurrence of extradigestive complications in patients with obesity
Variables
β-value
SE value
Wald value
P value
OR value
95%CI
History of hypertension
1.296
0.421
9.470
0.002
3.654
1.601-8.343
TC high
0.226
0.138
2.685
0.101
1.254
0.957-1.643
TG high
0.305
0.211
2.091
0.148
1.356
0.897-2.051
HDL-C high
-0.247
0.123
4.002
0.045
0.781
0.613-0.995
LDL-C high
0.909
0.254
12.787
< 0.001
2.481
1.508-4.085
PECAM-1 high
0.070
0.019
12.930
< 0.001
1.073
1.032-1.114
GDF11 high
-0.008
0.003
9.199
0.002
0.992
0.987-0.997
FGF21 high
0.024
0.007
13.062
< 0.001
1.024
1.011-1.038
Table 6 Receiver operating characteristic curve analysis of the serum levels of platelet endothelial cell adhesion molecule-1, growth differentiation factor 11, and fibroblast growth factor 21 in predicting the occurrence of extradigestive complications in patients with obesity
Indicators
Cut-of value
AUC (95%CI)
Sensitivity
Specificity
Jordon index
PECAM-1
40 μg/L
0.798 (0.595-0.974)
0.824
0.744
0.568
GDF11
650 μg/L
0.716 (0.509 -0.929)
0.716
0.733
0.449
FGF21
160 ng/L
0.813 (0.671-0.940)
0.811
0.791
0.602
Tripartite
0.909 (0.850-0.958)
0.919
0.884
0.803
Citation: Jiang L, Xu LL, Lu Y, Gu KF, Qian SY, Wang XP, Xu X. Effects and mechanisms of nutritional interventions on extradigestive complications in obese patients. World J Gastrointest Surg 2023; 15(11): 2482-2489