Observational Study
Copyright ©The Author(s) 2022.
World J Gastrointest Surg. Sep 27, 2022; 14(9): 1026-1036
Published online Sep 27, 2022. doi: 10.4240/wjgs.v14.i9.1026
Table 1 Comparison of tumor related detection index between gastric cancer and gastric polyp group
Indicator
Gastric polyp (n = 40)
Gastric cancer (n = 139)
P value
CEA1.16 (1.55, 2.11)1.11 (2.33, 5.11)0.014
AFP1.64 (2.63, 3.62)1.43 (2.24, 3.23)0.499
CA1256.86 (9.91, 14.81)8.56 (13.73, 24.39)0.033
CA1994.8 (7.74, 13.91)5.07 (10.52, 29.36)0.017
CA1536.53 (9.3, 12.54)6.42 (9.03, 13.15)0.268
CA7240.84 (1.34, 3.68)1.43 (3.33, 11)0.007
CY2111.32 (1.67, 2.35)1.7 (2.47, 4.46)0.390
Ferr63.86 (144.35, 268.48)26.19 (79.3, 174.4)0.176
NSE8.39 (10.06, 11.87)7.55 (9.27, 11.57)0.732
SCC0.43 (0.7, 1.08)0.5 (0.7, 1)0.247
PG1/21.3 (4.31, 6.26)0.67 (2.98, 4.26)0.008
PG27.65 (13.9, 29.68)9.9 (19.3, 32.4)0.199
PG112.83 (58.5, 115.93)20.3 (53.8, 82)0.255
Table 2 Comparison of clinical biochemical index gastric cancer and gastric polyp group
Indicator
Gastric polyp (n = 40)
Gastric cancer (n = 139)
P value
ALT11.73 (15.75, 19.35)10.7 (13.2, 18.3)0.322
AST13.93 (17.85, 20.45)13.1 (15.6, 18.6)0.252
TP64.73 (69.4, 72.3)61.9 (66.2, 69.4)0.095
ALB38.9 (41.5, 43.8)36.5 (38.9, 41)0.007
TB8.75 (11.8, 14.95)6.8 (9.4, 13.7)0.116
DB2.33 (3.65, 4.7)2.4 (3.3, 4.9)0.248
TBA2.65 (4.4, 5.98)2.6 (3.9, 7.4)0.622
ALP44.65 (66.85, 77.48)56.2 (65.2, 81.9)0.076
GGT13.13 (16.05, 27.43)13.3 (16.5, 24)0.773
GLu4.74 (5.27, 5.6)4.72 (5, 5.49)0.627
UN4.37 (5.22, 6.49)4.5 (5.21, 6.23)0.812
Cr58.83 (65.3, 75.15)57.5 (68.2, 77.8)0.838
UA261.1 (301.15, 371.9)228.4 (278.1, 330.5)0.117
CHO3.99 (4.34, 5.18)3.56 (4.16, 4.68)0.035
TG1.2 (1.46, 1.81)0.98 (1.25, 1.48)0.017
CK37.68 (55.9, 82.83)38.6 (56.8, 76.1)0.740
LDH139.65 (153.85, 174.43)118.1 (138, 158.9)0.792
CKMB3.15 (6.7, 10.73)2.4 (6.2, 9.3)0.357
Ca2.16 (2.26, 2.34)2.13 (2.19, 2.26)0.025
P1.31 (1.53, 1.81)1.2 (1.36, 1.51)0.008
Mg0.82 (0.87, 0.94)0.79 (0.85, 0.94)0.188
K3.76 (4.05, 4.41)3.79 (3.99, 4.29)0.319
Na141.23 (143.7, 146.35)141.3 (143.1, 144.5)0.579
Cl104.6 (106.6, 108.38)103.3 (105.3, 106.9)0.008
CO219.75 (22.15, 26.55)22.3 (24.9, 27.3)0.281
LP (a)6.14 (17.34, 35.2)9.51 (14.82, 26.13)0.582
HDL0.95 (1.12, 1.38)0.83 (1.03, 1.15)0.004
LDL2.33 (2.77, 3.34)1.98 (2.4, 2.93)0.010
ApoA11.08 (1.32, 1.59)0.96 (1.11, 1.24)0.001
ApoB0.7 (0.84, 1.04)0.66 (0.77, 0.9)0.021
CYS0.91 (1, 1.17)0.84 (0.96, 1.09)0.816
SA53.85 (61.4, 65.38)55.8 (64.5, 70.6)0.179
HCY9.85 (13.47, 16.5)10.63 (13.62, 17.74)0.414
CRP0.43 (0.9, 3.78)0.7 (1.9, 5.4)0.702
AMY47.2 (56.9, 77.23)40.9 (54.8, 68.1)0.433
LPS28.25 (34.85, 44.13)28.2 (35.7, 44.5)0.291
SOD141.33 (164.3, 189.5)108.3 (127.4, 157.4)0.001
IMA62.73 (66, 69.35)56 (60.2, 63.6)0.001
Table 3 Comparison of cytokine index gastric cancer and gastric polyp group
Indicator
Gastric polyp (n = 40)
Gastric cancer (n = 139)
P value
GM-CSF1.24 (2.7, 6.27)0.01 (0.53, 2.32)0.640
IFNγ0.08 (0.25, 1.08)0.01 (0, 0.82)0.585
IL-102.14 (3.39, 5.24)1.63 (4.06, 9.34)0.326
IL-1β0.02 (0.31, 1.14)0.01 (0.08, 0.94)0.905
IL-60.34 (0.94, 2.58)0.1 (1.98, 7.16)0.483
IL-823.73 (51.11, 112.94)39.4 (62.55, 138.23)0.697
MCP-1321.54 (429.78, 594.82)310.31 (448.27, 612.02)0.993
TNFα5.53 (7.09, 8.72)5.7 (9.87, 16.6)0.001
Table 4 Diagnostic value evaluation of single differential index for discriminating the gastric cancer and gastric polyp group
Indicator
AUC
P value
Lower
Upper
CEA0.6270.0140.5430.712
CA1250.6370.0080.5460.729
CA1990.5920.0780.5000.683
CA7240.702< 0.0010.6140.789
PG1/20.6280.0140.5170.738
ALB0.687< 0.0010.5850.788
CHO0.5990.0570.4990.700
TG0.6550.0030.5610.748
Ca0.6400.0070.5340.746
P0.6680.0010.5660.769
Cl0.6350.0090.5370.733
HDL0.6480.0040.5510.746
LDL0.6330.0100.5320.735
ApoA10.7020.0000.6020.802
ApoB0.6090.0360.5050.714
SOD0.755< 0.0010.6760.834
IMA0.790< 0.0010.7050.875
TNFα0.6560.0030.5750d.736
Table 5 Univariate and multivariate analysis of the differential index between gastric cancer and gastric polyp groups
Indicator
Univariate analysis
Multivariate analysis
Wals
P value
Exp (B)
Lower
Upper
Wals
P value
Exp (B)
Lower
Upper
CEA1.020.311.040.971.11
CA1251.530.220.990.981.01
CA7244.500.031.181.011.385.210.02 1.17 1.02 1.34
PG120.960.330.910.751.10
ALB0.010.930.990.851.16
TG0.790.370.640.231.72
Ca0.010.910.840.0419.42
P4.450.030.150.030.887.050.01 0.13 0.03 0.58
Cl2.730.100.850.711.03
HDL0.340.562.090.1725.09
LDL0.100.760.840.272.60
ApoA12.420.120.090.001.86
ApoB0.390.534.360.0445.13
SOD1.220.270.990.981.00
IMA4.500.030.890.790.9914.77< 0.001 0.85 0.78 0.92
TNFα3.070.081.080.991.19