Statistical proof of Helicobacter pylori eradication in preventing metachronous gastric cancer after endoscopic resection in an East Asian population

Table 1 Characteristics of included studies

First author	Country	Year	Follow-up years	Metachronous lesions	H. Pylori positive samples	Frequency		Mean age (yr)		Gender		Antrum/body/cardia		Ref.
						Eradicated	Persistent	Eradicated	Persistent	Eradicated (M/F)	Persistent (M/F)	Eradicated	Persistent
Uemura	Japan	1997	3 years	EGC	132	1/65	6/67	69.4	68.7	47/18	49/18	48/24/3	42/31/2	[20]
Nakagawa	Japan	2006	2 years	EGC	2825	8/356	129/2469	NA	NA	NA	NA	NA	NA	[21]
Fukase	Japan	2008	3 years	EGC	505	9/255	24/250	68	69	195/60	191/59	130/96/29	114/103/33	[22]
Shiotani	Japan	2008	24-48 mo	EGC	91	9/80	1/11	66		82/18		NA	NA	[23]
Han	Korea	2011	18-57 mo	EGC	116	4/94	2/22	70		NA	NA	NA	NA	[24]
Kim	Korea	2011	60 mo	EGC	55	0/28	5/27	62	60	19/10	17/9	14/10/4	15/7/5	[25]
Maehata	Japan	2012	3 years	EGC	268	15/177	13/91	68	72	128/49	66/25	70/91/16	34/48/9	[26]
Watari	Japan	2012	1 year	ER	185	3/79	10/106	NA	NA	NA	NA	NA	NA	[27]
Seo	Japan	2012	27 mo	EGC	74	0/61	0/13	NA	NA	NA	NA	NA	NA	[28]
Kim	Korea	2014	12 mo	EGC	156	2/49	16/107	59	64	39/10	73/34	39/7/3	90/12/5	[29]
Bae	Korea	2014	60 mo	EGC/dysplasia	667	34/485	24/182	62	64	380/105	145/37	NA	NA	[30]
Choi	Korea	2014	36 mo	EGC	880	10/439	17/441	59	61	291/148	305/136	325/101/13	313/113/15	[31]
Kwon	Korea	2014	3 years	EGC	283	10/214	10/69	61	60	141/73	49/20	197/10/7	63/4/2	[32]
Jung	Korea	2015	42 mo	EGC/dysplasia	675	10/169	21/506	NA	NA	NA	NA	NA	NA	[33]
Jeong	Korea	2015	NA	EGC	148	3/88	2/60	NA	NA	NA	NA	NA	NA	[34]
Kim	Korea	2016	30 mo	EGC	162	3/120	1/42	64	67	86/34	29/13	75/35/10	23/14/5	[35]
Ami	Japan	2017	53 mo	EGC	226	0/212	0/14	69		NA	NA	NA	NA	[36]
Kwon	Korea	2017	47 mo	EGC/dysplasia	395	33/368	8/27	NA	NA	NA	NA	NA	NA	[37]
Chung	Korea	2017	61 mo	EGC/dysplasia	185	17/167	7/18	67		NA	NA	NS	NA	[38]
Han	Korea	2017	60 mo	EGC	408	12/212	18/196	61	61	165/47	144/52	133/70/9	136/50/10	[39]
Choi	Korea	2018	5.9 years	EGC	396	14/194	27/202	59	59	141/53	157/45	160/25/9	166/27/9	[40]
Okada	Japan	2019	2 years	ESD	348	27/174	33/174	65	65	129/45	133/41	45/66/68	49/66/64	[41]
Yamamoto	Japan	2019	31.7 mo	Dysplasia	53	12/17	15/36	67	67	14/3	28/8	6/11/1	15/18/3	[42]

ESD: Endoscopic submucosal dissection; EGC: Early gastric cancer; ER: Endoscopic resection; H. pylori: Helicobacter pylori; NA: Not available.