Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Aug 27, 2022; 14(8): 867-873
Published online Aug 27, 2022. doi: 10.4240/wjgs.v14.i8.867
Statistical proof of Helicobacter pylori eradication in preventing metachronous gastric cancer after endoscopic resection in an East Asian population
Mohsen Karbalaei, Masoud Keikha
Mohsen Karbalaei, Department of Microbiology and Virology, School of Medicine, Jiroft University of Medical Sciences, Jiroft 78617-56447, Iran
Masoud Keikha, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 13131-99137, Iran
Author contributions: Karbalaei M and Keikha M contributed to conceptualization, data curation, original drafting, and manuscript review & editing; all authors critically reviewed and approved the final version of the manuscript before submitting.
Conflict-of-interest statement: There are no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Masoud Keikha, PhD, Doctor, Instructor, Teaching Assistant, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Vakilabad Blvd., Bahonar Blvd. Pardis campus, Mashhad 13131-99137, Iran. masoud.keykha90@gmail.com
Received: April 8, 2022
Peer-review started: April 8, 2022
First decision: May 11, 2022
Revised: May 29, 2022
Accepted: July 27, 2022
Article in press: July 27, 2022
Published online: August 27, 2022
Core Tip

Core Tip: Gastrointestinal infections caused by Helicobacter pylori (H. pylori) is one of the most well-known infections in the human digestive tract. This bacterium successfully has been colonized in the stomach of more than 4 billion people worldwide. In many developing countries, these microorganisms are colonized in childhood, which in later years may develop to severe complications, particularly gastric adenocarcinoma. In the present study, we statistically evaluated the effectiveness of H. pylori eradication in reducing the risk of tend to metachronous gastric cancer (MGC) in Asian populations. Our results suggested that the eradication of this pathogen significantly reduced the risk of susceptibility to MGC in these patients. However, based on the available evidence, several factors such as increasing age, severe atrophy in the corpus and antrum, and intestinal metaplasia all may increase the risk of MGC in H. pylori extirpated patients. Unfortunately, there is no detailed information about the location of the stomach where the reduction of gastric cancer can be achieved after H. pylori eradication. Therefore, in future studies, more research should be done on the recent puzzle.