Prognostic significance of the preoperative hemoglobin to albumin ratio for the short-term survival of gastric cancer patients

Table 1 Prognostic analysis of clinical characteristics in patients with gastric cancer

Clinical variable	n	Univariate analysis		Multivariate analysis
	312	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr)	62 (54-68)	1.046 (1.015-1.077)	0.003	1.049(1.017-1.081)	0.002
Sex (male/female)	225/87	0.715 (0.400-1.280)	0.259
BMI (kg/m2)	21.55 (19.53-23.55)	0.983 (0.911-1.062)	0.670
Smoking (yes/no)	64/248	0.442 (0.189-1.034)	0.060
Drinking (yes/no)	49/263	1.316 (0.641-2.701)	0.454
CEA (ng/mL)	2.94 (1.85-5.29)	1.006 (1.003-1.009)	0.000
CA19-9 (U/mL)	13.26 (7.36-23.70)	1.001 (1.000-1.002)	0.003
CA125 (U/mL)	8.50 (5.90-13.80)	1.008 (1.000-1.016)	0.049
CA72-4 (IU/mL)	1.81 (1.17-4.46)	1.004 (0.990-1.018)	0.57
HAR	3.18 (2.68-3.44)	0.425 (0.278-0.650)	0.000	0.466 (0.301-0.720)	0.001
PHR	1.86 (1.40-2.58)	1.371 (1.194-1.575)	0.000
PLR	157.74 (114.06-211.23)	1.003 (1.001-1.006)	0.004
PAR	5.75 (4.51-7.48)	1.184 (1.088-1.288)	0.000
FLR	2.05 (1.49-2.89)	1.171 (1.018-1.347)	0.028
AFR	13.16 (10.36-16.85)	0.970 (0.912-1.033)	0.344
HFR	42.52 ± 17.83	0.974 (0.955-0.993)	0.007
PFR	77.41 (57.84-101.46)	1.005 (0.998-1.012)	0.135
NLR	2.47 (1.76-3.59)	1.100 (0.974-1.242)	0.124
ALR	26.25 (22.16-35.08)	1.008 (0.986-1.030)	0.489
Tumor size (cm)	4.0 (2.5-5.5)	1.167 (1.079-1.262)	0.000
Vascular infiltration (present/absent)	168/144	3.230 (1.695-6.153)	0.000
Nerve infiltration (present/absent)	149/163	2.974 (1.651-5.359)	0.000
Histological grade (G1/G2/G3)	6/120/186	0.920 (0.553-1.530)	0.748
Stage (Ⅰ/Ⅱ/Ⅲ)	88/75/149	4.154 (2.291-7.531)	0.000	4.112 (2.225-7.602)	0.000
Survival status (death/survival)	53/259
Follow-up time (d)	531 (440-691)

BMI: Body mass index; PHR: Platelet to hemoglobin ratio; PLR: Platelet to lymphocyte ratio; PAR: Platelet to albumin ratio; FLR: Fibrinogen to lymphocyte ratio; AFR: Albumin to fibrinogen ratio; HFR: Hemoglobin to fibrinogen ratio; PFR: Platelet to fibrinogen ratio; NLR: Neutrophil to lymphocyte ratio; ALR: Albumin to lymphocyte ratio. HR: Hazard ratio; CI: Confidence interval; HAR: Hemoglobin to albumin ratio.

Table 2 Hemoglobin to albumin ratio value associated with clinical pathological characteristics

Clinical characteristics	Total (n)	Odds ratio in HAR value	P value
Age (≥ 62 yr vs < 62 yr)	312	0.78 (0.50-1.21)	0.264
Size (≥ 4 cm vs < 4 cm)	312	0.51 (0.32-0.80)	0.004
Histological grade
(G2 vs G1)	126	0.91 (0.16-5.06)	0.905
(G3 vs G1)	192	1.00 (0.18-5.52)	1.000
Vascular infiltration (yes vs no)	312	1.14 (0.73-1.79)	0.552
Nerve infiltration (yes vs no)	312	1.00 (0.64-1.56)	0.988
Stage
(Ⅱ vs I)	163	0.45 (0.24-0.83)	0.012
(Ⅲ vs I)	237	0.48 (0.28-0.81)	0.007
T classification
(T2 vs T1)	106	0.61 (0.27-1.39)	0.243
(T3 vs T1)	112	0.62 (0.28-1.35)	0.227
(T4 vs T1)	236	0.52 (0.29-0.91)	0.022
N classification
(N1 vs N0)	169	0.76 (0.33-1.74)	0.518
(N2 vs N0)	201	0.56 (0.30-1.04)	0.067
(N3 vs N0)	226	0.68 (0.39-1.16)	0.160

HAR: Hemoglobin to albumin ratio.

Table 3 Comparison of the relevant factors between the high hemoglobin to albumin ratio group and low hemoglobin to albumin ratio group

Factors	High HAR group (n = 158)	Low HAR group (n = 154)	P value
Age (yr)	61 (53-67)	63 (54-69)	0.266
Sex (n)			0.000
Male	132	93
Female	26	61
BMI (kg/m2)	21.81 (19.90-23.82)	21.30 (19.32-23.33)	0.154
Smoking (n)			0.468
Yes	35	29
No	123	125
Drinking (n)			0.322
Yes	28	21
No	130	133
CEA (ng/mL)	2.89 (1.87-5.23)	2.97 (1.83-5.44)	0.581
CA19-9 (U/mL)	12.63 (7.43-21.52)	13.38 (7.23-24.20)	0.658
CA125 (U/mL)	8.30 (5.68-11.30)	9.15 (6.08-16.80)	0.034
CA72-4 (IU/mL)	1.91 (1.19-4.46)	1.73 (1.14-4.46)	0.396
PHR	1.55 (1.25-1.95)	2.29 (1.71-3.36)	0.000
PLR	138.71 (98.29-188.22)	177.27 (134.34-252.12)	0.000
PAR	5.49 (4.36-6.86)	6.04 (4.70-8.20)	0.002
FLR	1.83 (1.39-2.62)	2.26 (1.57-3.11)	0.001
AFR	13.73 (10.92-16.83)	12.62 (9.69-16.93)	0.162
HFR	48.46 ± 14.63	36.42 ± 18.78	0.000
PFR	73.48 (57.12-92.62)	79.78 (60.16-112.23)	0.040
NLR	2.32 (1.74-3.36)	2.89 (1.92-3.78)	0.024
ALR	24.40 (19.05-32.52)	27.87 (23.08-35.77)	0.000
Tumor size (cm)	3.5 (2.4-5.0)	4.5 (3.0-6.1)	0.009
Vascular infiltration (n)			0.507
present	88	80
absent	70	74
Nerve infiltration (n)			0.918
present	75	74
absent	83	80
Histological grade (n)			0.682
G1	3	3
G2	59	61
G3	96	90
Stage (n)			0.036
Ⅰ	56	32
Ⅱ	32	43
Ⅲ	70	79
T classification (n)			0.037
T1	44	27
T2	18	17
T3	20	21
T4	76	89
N classification (n)			0.141
N0	79	63
N1	14	13
N2	25	34
N3	40	44

HAR: Hemoglobin to albumin ratio; BMI: Body mass index; PHR: Platelet to hemoglobin ratio; PLR: Platelet to lymphocyte ratio; PAR: Platelet to albumin ratio; FLR: Fibrinogen to lymphocyte ratio; AFR: Albumin to fibrinogen ratio; HFR: Hemoglobin to fibrinogen ratio; PFR: Platelet to fibrinogen ratio; NLR: Neutrophil to lymphocyte ratio; ALR: Albumin to lymphocyte ratio.