Timing of individualized surgical intervention in Crohn’s disease

Table 1 Correlations between drug factors and surgical complications of Crohn’s disease

Ref.	Drugs	Type of study	Number of patients	Observations	Conclusion
Cohen et al[68], 2022	TNFis	Prospective study	947	Postoperative infection rate	No correlation
Uchino et al[69], 2022	TNFis	Retrospective study	305	Surgical mortality	No correlation
Abd El Aziz et al[70], 2022	TNFis	Prospective study	274	Intra-abdominal septic complications	No correlation
Azzam et al[71], 2022	Azathioprine	Retrospective study	105	Endoscopic recurrence rate	Negative correlation
Cosnes et al[72], 2005	Azathioprine	Retrospective study	2573	Intestinal complications	No correlation
Nguyen et al[73], 2014	Steroids	Retrospective study	15495	Postoperative sepsis and VTE	Positive correlation

TNFis: Tumor necrosis factor inhibitors; VTE: Venous thromboembolism.