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World J Gastrointest Surg. Dec 27, 2022; 14(12): 1320-1328
Published online Dec 27, 2022. doi: 10.4240/wjgs.v14.i12.1320
Timing of individualized surgical intervention in Crohn’s disease
Kai Xia, Ren-Yuan Gao, Xiao-Cai Wu, Lu Yin, Chun-Qiu Chen
Kai Xia, Ren-Yuan Gao, Xiao-Cai Wu, Lu Yin, Chun-Qiu Chen, Diagnostic and Treatment Center for Refractory Diseases of Abdomen Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
Author contributions: Xia K drafted the manuscript, and collected and organized the literature; Gao RY, Wu XC, Yin L, and Chen CQ contributed to manuscript modification.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Qiu Chen, Doctor, Chief Doctor, Professor, Diagnostic and Treatment Center for Refractory Diseases of Abdomen Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301 Yanchang Middle Road, Shanghai 200072, China. chenchunqiu6@126.com
Received: September 1, 2022
Peer-review started: September 1, 2022
First decision: October 20, 2022
Revised: October 24, 2022
Accepted: December 1, 2022
Article in press: December 1, 2022
Published online: December 27, 2022
Processing time: 116 Days and 22.9 Hours
Abstract

Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract with an increasing incidence worldwide. Comprehensive therapy for CD focuses on symptom control and healing the intestinal mucosa to improve the quality of life and prevent complications. Surgical intervention plays a vital role in comprehensive therapy. However, deciding the optimal timing for surgical intervention has long been a focus of controversy. This review provides insights into the timing of surgery for CD and guides clinicians in daily treatment.

Keywords: Crohn’s disease; Surgical intervention; Timing of surgery; Individualization; Therapy

Core Tip: Surgical intervention plays an important role in the comprehensive treatment of Crohn’s disease (CD). However, the timing of surgery has always been a major controversial point. This review focuses on the main surgical indications for CD and the clinical factors that may influence surgical timing decisions. We also emphasize the value of early surgery in treating CD.