Compare clinical efficacy and safety of neoadjuvant therapy and neoadjuvant chemoradiotherapy for locally advanced rectal cancer: Meta-analysis

Figure 1 Flow chart of the literature screening. ¹Consider, if feasible to do so, reporting the number of records identified from each database or register searched (rather than the total number across all databases/registers). ²If automation tools were used, indicate how many records were excluded by a human and how many were excluded by automation tools.

Figure 2 Risk of bias graph of the literature quality evaluation chart.

Figure 3 Comparative analysis of acute grade 3/4 toxicity, perioperative complications, pathologic complete response rates, the rate of decrease in tumor T stage, the R0 removal rate, anal preservation rates, local recurrence, and distant metastasis between total neoadjuvant therapy and neoadjuvant chemoradiotherapy. A: Comparative analysis of acute grade 3/4 toxicity between total neoadjuvant therapy (TNT) and neoadjuvant chemoradiotherapy (nCRT); B: Comparative analysis of perioperative complications between the TNT and nCRT groups; C: Comparative analysis of pathologic complete response rates between the TNT and nCRT groups; D: Comparative analysis of the rate of decrease in tumor T stage between the TNT and nCRT groups; E: Comparative analysis of the R0 removal rate between the TNT and nCRT groups; F: Comparative analysis of anal preservation rates between the TNT and nCRT groups; G: Comparative analysis of local recurrence between the TNT and nCRT groups; H: Comparative analysis of distant metastasis between the TNT and nCRT groups. TNT: Total neoadjuvant therapy; nCRT: Neoadjuvant chemoradiotherapy; CI: Confidence interval.

Figure 4 Comparative analysis of 5-year overall survival and disease-free survival between the total neoadjuvant therapy and neoadjuvant chemoradiotherapy groups. A: 5-year overall survival; B: 5-year disease-free survival. TNT: Total neoadjuvant therapy; nCRT: Neoadjuvant chemoradiotherapy; CI: Confidence interval.

Figure 5 Publication bias of included studies. OR: Odds ratio.