Wang Y, Yang Y, Liu QQ, Wang SZ. Compare clinical efficacy and safety of neoadjuvant therapy and neoadjuvant chemoradiotherapy for locally advanced rectal cancer: Meta-analysis. World J Gastrointest Surg 2024; 16(6): 1845-1856 [PMID: 38983334 DOI: 10.4240/wjgs.v16.i6.1845]
Corresponding Author of This Article
Shao-Zhao Wang, MM, Doctor, Department of Anorectal Words, Central Hospital Affiliated Shandong First Medical University, No. 105 Jiefang Road, Jinan 250013, Shandong Province, China. wangsztcm@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jun 27, 2024; 16(6): 1845-1856 Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1845
Compare clinical efficacy and safety of neoadjuvant therapy and neoadjuvant chemoradiotherapy for locally advanced rectal cancer: Meta-analysis
Ying Wang, Yan Yang, Qi-Qi Liu, Shao-Zhao Wang
Ying Wang, Department of Anus Intestinal Surgery, Feicheng People’s Hospital, Feicheng 271600, Shandong Province, China
Yan Yang, Department of Gastroenterology, Qingdao Hospital of University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao 266011, Shandong Province, China
Qi-Qi Liu, Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Shao-Zhao Wang, Department of Anorectal Words, Central Hospital Affiliated Shandong First Medical University, Jinan 250013, Shandong Province, China
Author contributions: Wang Y wrote the manuscript; Yang Y and Liu QQ collected the data; Wang SZ guided the study; and all authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Zhao Wang, MM, Doctor, Department of Anorectal Words, Central Hospital Affiliated Shandong First Medical University, No. 105 Jiefang Road, Jinan 250013, Shandong Province, China. wangsztcm@163.com
Received: January 19, 2024 Revised: April 1, 2024 Accepted: April 28, 2024 Published online: June 27, 2024 Processing time: 162 Days and 23 Hours
Core Tip
Core Tip: The main aim of this study was to perform a meta-analysis and compare the clinical efficacy and safety of neoadjuvant therapy and neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer. We will collect and synthesize relevant research data to evaluate the performance of the two treatments in terms of the tumor shrinkage rate, surgical resection rate, tumor-free survival rate and other clinical indicators and analyze the safety differences between the two treatments in terms of the incidence of serious adverse events and other aspects. Through in-depth exploration of the advantages and disadvantages of the two treatment schemes, the aim is to provide more guiding treatment suggestions for clinicians to optimize the choice of treatment schemes for patients and improve the treatment effect and quality of life.
