Clinical Practice Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2017; 9(12): 270-280
Published online Dec 27, 2017. doi: 10.4240/wjgs.v9.i12.270
Risk factors for pancreatic fistula following pancreaticoduodenectomy: A retrospective study in a Thai tertiary center
Narongsak Rungsakulkij, Somkit Mingphruedhi, Pongsatorn Tangtawee, Chonlada Krutsri, Paramin Muangkaew, Wikran Suragul, Penampai Tannaphai, Suraida Aeesoa
Narongsak Rungsakulkij, Somkit Mingphruedhi, Pongsatorn Tangtawee, Chonlada Krutsri, Paramin Muangkaew, Wikran Suragul, Suraida Aeesoa, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
Penampai Tannaphai, Department of Radiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
Author contributions: Rungsakulkij N contributed to design of the work, data collection, interpretation of data, writing and drafting the work; Mingphruedhi S, Tangtawee P and Krutsri C contributed to data collection and analysis; Muangkaew P, Suragul W and Tannapai P contributed to data collection; Aeesoa S contributed to data analysis.
Institutional review board statement: The study was reviewed and approved by the Ramathibodi Hospital Institutional Review Board Committee on Human Rights Related to Research Involving Human Subjects. The protocol number is ID 12-59-50.
Informed consent statement: Not applicable.
Conflict-of-interest statement: All authors have no conflict of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Narongsak Rungsakulkij, MD, FRCS (Gen Surg), Lecturer, Surgeon, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ramathibodi Hospital, 270 Praram VI road, Ratchathewi, Bangkok 10400, Thailand. narongsak.run@mahidol.ac.th
Telephone: +66-2-2011527 Fax: +66-2-2012471
Received: July 24, 2017
Peer-review started: July 26, 2017
First decision: September 11, 2017
Revised: September 15, 2017
Accepted: October 30, 2017
Article in press: October 30, 2017
Published online: December 27, 2017
Processing time: 155 Days and 19.1 Hours
Core Tip

Core tip: Pancreaticoduodenectomy is a high morbidity operation. The most common perioperative complication is postoperative pancreatic fistula. We retrospectively analyzed 179 patients who underwent pancreaticoduodenectomy at our hospital. We found that soft pancreatic tissue is the most significant risk factor for postoperative pancreatic fistula. A high preoperative serum bilirubin level (> 3 mg/dL) is the most significant risk factor for clinically relevant pancreatic fistula.