Retrospective Cohort Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2016; 8(10): 685-692
Published online Oct 27, 2016. doi: 10.4240/wjgs.v8.i10.685
Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?
Krashna Patel, Khaled Dajani, Satheesh Iype, Nikolaos A Chatzizacharias, Saranya Vickramarajah, Prateush Singh, Susan Davies, Rebecca Brais, Siong S Liau, Simon Harper, Asif Jah, Raaj K Praseedom, Emmanuel L Huguet
Krashna Patel, Khaled Dajani, Satheesh Iype, Nikolaos A Chatzizacharias, Prateush Singh, Siong S Liau, Simon Harper, Asif Jah, Raaj K Praseedom, Emmanuel L Huguet, Department of Surgery, Hepato-Pancreato-Biliary Unit, Addenbrooke’s Hospital, Cambridge CB20XZ, United Kingdom
Saranya Vickramarajah, Department of Upper Gastrointestinal Surgery, Addenbrooke’s Hospital, Cambridge CB20XZ, United Kingdom
Susan Davies, Rebecca Brais, Department of Histopathology, Addenbrooke’s Hospital, Cambridge CB20XZ, United Kingdom
Author contributions: All the authors contribute to the manuscript.
Institutional review board statement: The study was reviewed and approved by the Hepatopancreatobiliary Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent at the time of the operation prior to the study.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at emmanuel.huguet@addenbrookes.nhs.uk. Participants’ consent was not obtained for data sharing but the presented data are anonymized with no risk of identification.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Emmanuel L Huguet, MD, PhD, Consultant Hepato-Pancreato-Biliary surgeon, Department of Surgery, Hepato-Pancreato-Biliary Unit, Addenbrooke’s Hospital, Hills Road, Cambridge CB20XZ, United Kingdom. emmanuel.huguet@addenbrookes.nhs.uk
Telephone: +44-1223-257074 Fax: +44-1223-216015
Received: May 9, 2016
Peer-review started: May 11, 2016
First decision: June 14, 2016
Revised: August 4, 2016
Accepted: August 15, 2016
Article in press: August 16, 2016
Published online: October 27, 2016
Processing time: 169 Days and 15.5 Hours
Core Tip

Core tip: The selective use of histopahological examination of gallbladders removed during routine cholecystectomy has been advocated by several authors in the literature. We present a large single centre study demonstrating a full range of gallbladder disease from cholecystectomy specimens, including more than 1% neoplastic histology and two cases of microscopic gallbladder malignancies in macroscopically normal gallbladders. On this basis, routine histological evaluation of all elective and emergency cholecystectomies is justified in an United Kingdom population as selective analysis has potential to miss potentially curable life threatening pathology.