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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2015; 7(7): 116-122
Published online Jul 27, 2015. doi: 10.4240/wjgs.v7.i7.116
Published online Jul 27, 2015. doi: 10.4240/wjgs.v7.i7.116
Accuracy of computed tomography in nodal staging of colon cancer patients
Audrey H Choi, Hans F Schoellhammer, Won Cho, Michelle Ko, Amanda Arrington, Christopher R Oxner, Stephen M Sentovich, Julio Garcia-Aguilar, Joseph Kim, Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010, United States
Rebecca A Nelson, Department of Biostatistics, City of Hope National Medical Center, Duarte, CA 91010, United States
Marwan Fakih, Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010, United States
Jimmie Wong, Department of Radiology, City of Hope National Medical Center, Duarte, CA 91010, United States
Author contributions: Choi AH and Nelson RA contributed equally to this work; Garcia-Aguilar J and Kim J designed the research; Choi AH, Schoelhammer HF, Cho W, Ko M, Arrington A, Oxner CR, Wong J and Garcia-Aguilar J acquired the data; Choi AH, Nelson RA, Schoelhammer HF, Cho W and Oxner CR analyzed the data; Choi AH, Nelson RA, Schoelhammer HF, Cho W and Ko M wrote the manuscript; Arrington A, Oxner CR, Fakih M, Wong J, Sentovich SM, Garcia-Aguilar J and Kim J provided critical revisions for intellectual content; all authors provided final approval of the manuscript.
Institutional review board statement: The study was reviewed and approved by the City of Hope Institutional Review Board.
Informed consent statement: N/A.
Conflict-of-interest statement: The authors have no relevant disclosures pertaining to this work.
Data sharing statement: Dataset available from the corresponding author at jokim@coh.org.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Joseph Kim, MD, Department of Surgery, City of Hope National Medical Center, 1500 East Duarte Rd, Duarte, CA 91010, United States. jokim@coh.org
Telephone: +1-626-4767100 Fax: +1-626-3018865
Received: March 3, 2015
Peer-review started: March 3, 2015
First decision: March 20, 2015
Revised: April 6, 2015
Accepted: June 9, 2015
Article in press: June 11, 2015
Published online: July 27, 2015
Peer-review started: March 3, 2015
First decision: March 20, 2015
Revised: April 6, 2015
Accepted: June 9, 2015
Article in press: June 11, 2015
Published online: July 27, 2015
Core Tip
Core tip: Clinical staging to determine eligibility for neoadjuvant trials requires accurate imaging. This study compares lymph node identification on preoperative computed tomography (CT) scans by outside radiologists, a tertiary cancer center radiologist and a surgeon, mirroring referral patterns to tertiary care facilities. While re-review of CT scans by a tertiary center radiologist improved sensitivity of lymph node detection, CT staging of colon cancer demonstrated moderate accuracy overall. Our findings suggest that the administration of neoadjuvant chemotherapy based on preoperative CT staging would potentially result in overtreatment of colon cancer patients.