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World J Gastrointest Surg. Jun 27, 2015; 7(6): 86-93
Published online Jun 27, 2015. doi: 10.4240/wjgs.v7.i6.86
Intraoperative blood loss in orthotopic liver transplantation: The predictive factors
Chandra Kant Pandey, Anshuman Singh, Kamal Kajal, Mandeep Dhankhar, Manish Tandon, Vijay Kant Pandey, Sunaina Tejpal Karna
Chandra Kant Pandey, Anshuman Singh, Kamal Kajal, Mandeep Dhankhar, Manish Tandon, Vijay Kant Pandey, Sunaina Tejpal Karna, Department of Anaesthesiology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi 110070, India
Author contributions: Pandey CK collected the references, conceived the concept, wrote the manuscript, revised and did the editing works; Singh A, Kajal K, Dhankhar M, Tandon M, Pandey VK and Karna ST wrote the manuscript, revised and did the editing works; all the above authors contributed equally in writing the manuscript, revising and did the editing works.
Conflict-of-interest: We, the authors of the manuscript hereby testify that none of us have received fees for serving as a speaker/consultant/advisory board member for any of organization. None of the authors have received research funding from any organization. None of the authors own stocks and/or shares in their names or concerned organizations. None of the authors own any relevant patents.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chandra Kant Pandey, MD, Senior Professor and Head, Department of Anaesthesiology, Institute of Liver and Biliary Sciences, Sector D-1, Vasant Kunj, New Delhi 110070, India. ceekeypandey@gmail.com
Telephone: +91-95-40946851 Fax: +91-11-26123504
Received: January 12, 2015
Peer-review started: January 15, 2015
First decision: March 20, 2015
Revised: April 13, 2015
Accepted: April 28, 2015
Article in press: April 30, 2015
Published online: June 27, 2015
Processing time: 163 Days and 24 Hours
Core Tip

Core tip: Liver transplantation has been associated with massive blood loss and considerable transfusion requirements. The bleeding in orthotopic liver transplantation is multifactorial such as etiology and severity of liver disease, preexisting coagulopathy, previous abdominal surgeries, preoperative hematocrit, surgical techniques and methods of clamping, experience of surgical team, central venous pressure, the use of antifibrinolytics and procoagulants and use of point of care monitoring during the transplantation. The purpose of this review is to discuss the risk factors predictive of increased intra-operative bleeding in patients undergoing orthotopic liver transplant.