Review
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World J Gastrointest Surg. Jul 27, 2014; 6(7): 122-128
Published online Jul 27, 2014. doi: 10.4240/wjgs.v6.i7.122
Mechanisms of hepatic ischemia-reperfusion injury and protective effects of nitric oxide
Lian-Yue Guan, Pei-Yao Fu, Pei-Dong Li, Zhuo-Nan Li, Hong-Yu Liu, Min-Gang Xin, Wei Li
Lian-Yue Guan, Pei-Yao Fu, Pei-Dong Li, Zhuo-Nan Li, Hong-Yu Liu, Wei Li, Department of Hepatobiliary-Pancreatic Surgery, Third Hospital (China-Japan Union Hospital) of Jilin University, Changchun 130033, Jilin Province, China
Min-Gang Xin, Departments of Anesthesiology, Third Hospital (China-Japan Union Hospital) of Jilin University, Changchun 130033, Jilin Province, China
Author contributions: Guan LY and Fu PY contributed equally to the paper; Guan LY primarily drafted the article; Fu PY performed the intensive revision and drew the two figures; Li PD drafted the nitric oxide portion of the manuscript; Li ZN, Liu HY and Xin MG conducted the data collection and interpretation, selected the references, and drafted the discussion; Li W contributed to the concept design, critical revision and finalization of the manuscript.
Supported by National Natural Science Foundation of China, No. 81170416 and No. 81273264; Doctoral Fund of Ministry of Education of China, No. 20100061110069; Jilin Province Science and Technology Bureau International Cooperation Fund, No. 2011742; Techpool Research Fund, No. 01201046; Jilin Province Nature Science Foundation, No. 201015178
Correspondence to: Wei Li, MD, PhD, Department of Hepatobiliary-Pancreatic Surgery, Third Hospital (China-Japan Union Hospital) of Jilin University, 126 Xiantai Street, Changchun 130033, Jilin Province, China. weili888@hotmail.com
Telephone: +86-431-89876816 Fax: +86-431-84641026
Received: January 4, 2014
Revised: May 26, 2014
Accepted: June 20, 2014
Published online: July 27, 2014
Processing time: 201 Days and 19.9 Hours
Core Tip

Core tip: This review provides insights into several key mechanisms of liver ischemia-reperfusion injury, including the effects of anaerobic metabolism and the role of mitochondria, oxidative stress, intracellular calcium overload, liver Kupffer cells and neutrophils, and cytokines and chemokines; and summarizes the protective effects of nitric oxide.