Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Aug 27, 2025; 17(8): 108579
Published online Aug 27, 2025. doi: 10.4240/wjgs.v17.i8.108579
Outcomes of iodine-125 seed strips combined with double self-expandable metallic stent for Bismuth type III and IV malignant biliary obstruction
Chuan-Guo Zhou, Yong Zhang, Hui Li, Ke-Yun Liu, Xiang-Yu Yang, Kun Gao
Chuan-Guo Zhou, Yong Zhang, Hui Li, Ke-Yun Liu, Xiang-Yu Yang, Kun Gao, Department of Interventional Radiology, Beijing Chaoyang Hospital, The Affiliated Hospital of Capital Medical University, Beijing 100020, China
Co-corresponding authors: Chuan-Guo Zhou and Kun Gao.
Author contributions: Zhou CG analyzed the data, wrote and revised the manuscript; Zhou CG and Gao K conceived and designed the study, confirmed the authenticity of all raw data as the co-corresponding authors; Zhou CG, Zhang Y, Li H, Liu KY, Yang XY, and Gao K performed the interventional procedure; all authors have read and approved the manuscript.
Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Informed consent statement: Informed consent from the patients was waived by the committee because the study was retrospective.
Conflict-of-interest statement: We have no financial relationships to disclose.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chuan-Guo Zhou, MD, Department of Interventional Radiology, Beijing Chaoyang Hospital, The Affiliated Hospital of Capital Medical University, No. 8 Gongren Tiyuchang Nan Road, Chaoyang District, Beijing 100020, China. zhoucg3949_cn@sina.com
Received: April 22, 2025
Revised: May 30, 2025
Accepted: June 30, 2025
Published online: August 27, 2025
Processing time: 125 Days and 21.8 Hours
Core Tip

Core Tip: This study explores the innovative use of iodine-125 seed strips combined with double self-expandable metallic stent for treating Bismuth type III and IV hilar malignant biliary obstruction. In a retrospective analysis of 17 patients from April 2017 to December 2022, we achieved a technical success rate of 94.1% and a clinical success rate of 100%. The median overall survival was 189 days, with stent patency lasting an average of 154 days. No serious complications were reported, indicating that this combination therapy is a safe and effective treatment option for these patients.