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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2025; 17(7): 107099
Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.107099
Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.107099
TONEFACT: Can even advanced hemorrhoids be treated without surgery? A paradigm shift in the management of hemorrhoids
Pankaj Garg, Department of Colorectal Surgery, Garg Fistula Research Institute, Panchkula 134113, Haryana, India
Inna Tulina, Department of Oncologic Colorectal Surgery, Sechenov First Moscow State Medical University, Moscow 119991, Russia
Dong-Lin Ren, Department of Coloproctology, The Sixth Affiliated Hospital of Sun Yat-sen University (Gastrointestinal & Anal Hospital of Sun Yat-sen University), Guangzhou 510655, Guangdong Province, China
Kaushik Bhattacharya, Department of Surgery, MGM Medical College and LSK Hospital, Kishanganj 855107, Bihar, India
Vipul D Yagnik, Department of Surgery, Banas Medical College and Research Institute, Palanpur 385001, Gujarat, India
Garg Mahak, Clinical Research, Garg Fistula Research Institute, Panchkula 134113, Haryāna, India
Author contributions: Garg P conceived and designed the study, collected and analyzed the data, revised the data, and approved and submitted the manuscript (guarantor of the study); Tulina I collected and analyzed the data, revised the data, and approved and submitted the manuscript; Ren DL critically analyzed the data, reviewed and edited the manuscript, and approved and submitted the manuscript; Bhattacharya K analyzed the data, revised the data, and approved and submitted the manuscript; Yagnik VD analyzed the data, revised the data, and approved and submitted the manuscript; Mahak G analyzed the data, revised the data, and approved and submitted the manuscript.
Conflict-of-interest statement: The authors have nothing to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pankaj Garg, Department of Colorectal Surgery, Garg Fistula Research Institute, 1042, Sector-15, Panchkula 134113, Haryana, India. drgargpankaj@gmail.com
Received: March 16, 2025
Revised: April 23, 2025
Accepted: May 28, 2025
Published online: July 27, 2025
Processing time: 130 Days and 17.9 Hours
Revised: April 23, 2025
Accepted: May 28, 2025
Published online: July 27, 2025
Processing time: 130 Days and 17.9 Hours
Core Tip
Core Tip: Hemorrhoids are one of the most prevalent disorders. Many patients with hemorrhoids undergo surgery as treatment, especially in advanced grades (late grade II, grade III & grade IV) and hemorrhoids with uncontrolled bleeding. TONEFACT is a novel treatment that rectifies the root cause of hemorrhoids, thereby stopping the progression and causing the cessation of symptoms (bleeding and thrombosis). Thus, it removes the requirement of surgery in a good proportion of patients who were indicated for surgery. Considering the high prevalence rate of the disease, this amounts to enormous savings in hospital admissions and surgical morbidity at the global level.