Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Apr 27, 2025; 17(4): 102697
Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.102697
Risk factors for bile leakage after laparoscopic common bile duct exploration in older patients with choledocholithiasis
Ruo-Fei Xiong, Shan-Shan Lu, Zhi-Ming Wu, Hong-Jun Huang, Tao Xiao
Ruo-Fei Xiong, Zhi-Ming Wu, Hong-Jun Huang, Department of General Surgery, Shaoxing Central Hospital, Shaoxing 312000, Zhejiang Province, China
Shan-Shan Lu, Department of Geriatrics, Shaoxing University Affiliated Hospital, Shaoxing 312000, Zhejiang Province, China
Tao Xiao, Department of General Surgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Co-first authors: Ruo-Fei Xiong and Shan-Shan Lu.
Author contributions: Xiong RF, Lu SS, and Wu ZM were responsible for the conception and design of the study and drafting the article; Xiong RF and Lu SS contributed equally to this article as co-first authors; Xiong RF, Lu SS, Wu ZM, and Huang HJ contributed to the data analysis and interpretation; Huang HJ contributed to acquisition of the data; Xiao T was responsible for revising the manuscript critically for important intellectual content, and final approval of the version to be submitted; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Ke Qiao Science and Technology Plan Projects, No. 2022KZ70.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Shaoxing Central Hospital, approval No. 2023029.
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Dataset is available from the corresponding author by e-mail at xiaotao@ncu.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tao Xiao, MD, Department of General Surgery, First Affiliated Hospital of Nanchang University, No. 17 Yong Wai Zheng Street, Nanchang 330006, Jiangxi Province, China. xiaotao@ncu.edu.cn
Received: October 28, 2024
Revised: January 13, 2025
Accepted: February 12, 2025
Published online: April 27, 2025
Processing time: 154 Days and 16.3 Hours
Core Tip

Core Tip: This is a retrospective single-center observational study to investigate the potential risk factors for bile leakage after laparoscopic common bile duct exploration in elderly patients. Enterococcus faecalis (E. faecalis) is an independent risk factor for postoperative bile leakage in elderly patients. The results of drug sensitivity analysis showed that E. faecalis was fully sensitive to penicillin, ampicillin, linezolid, vancomycin, and furantoin. In elderly patients with choledocholithiasis who are at risk of postoperative bile leakage, we suggest covering sensitive drugs for E. faecalis in the empiric regimen of antibiotics.